# About AMDB
Animal metabolite database (AMDB) is a freely accessible database on the quantitative content of metabolites in the tissues of animals. The AMDB is designed to ease browsing and comparing the quantitative metabolomics data and the raw NMR and MS data, as well as the sample metadata. Moreover, the AMDB is a platform, serving the metabolomics community for the convenient deposition and exchange of ‘eternal’ quantitative metabolomics data. The concentrations of most abundant metabolites (typically, 60-90 compounds for each sample) in tissues are obtained mostly with the NMR method and are given in nanomoles per gram of wet tissue weight (nmol/g).
To date, the AMDB generally covers the metabolite content of the tissues of vertebrates, primarily wild species from Siberia, Russia and laboratory rodents, with the focus on the eye lens, although the data on other tissues (blood, muscle, heart, liver, brain, etc.) are also present. The list of [Species](../amdb/taxonomy/tree/) page and tissues studied by our group is constantly growing.
A [Sample](../amdb/samples/list/) describes information obtained from a certain tissue of a certain individual animal. Each sample contains data on the metabolite concentrations, the raw data from the instrument (NMR or LC-MS), and the metadata (species, age, weight, location, etc.) describing the sample.
Samples that are rather uniform i.e. from one species, one tissue, and one disease/factor are combined into [Groups](../amdb/groups/list/) of samples.
Sample groups are further compared in completed [Experiments](../amdb/experiments/list/).
[Metabolites](../amdb/metabolites/list/) page contains information about the detected and quantified metabolites in the tissues of species, including those identified de-novo in our laboratory. Metabolites also contain links to other databases (PubChem, HMDB, KEGG, ChEBI) if such entry exist in a database.
[Currently](../statistics/), AMDB contains 46 species, 13 tissues, 741 samples, 146 quantified metabolites, and more that 40 000 measured concentration values.
Information on [How to use the database](/help/) is described in Help/Tutorial page.
***Publication:*** Vadim V. Yanshole, Arsenty D. Melnikov, Lyudmila V. Yanshole, Ekaterina A. Zelentsova, Olga A. Snytnikova, Nataliya A. Osik, Maxim V. Fomenko, Ekaterina D. Savina, Anastasia V. Kalinina, Kirill A. Sharshov, Nikita A. Dubovitskiy, Mikhail S. Kobtsev, Anatolii A. Zaikovskii, Sofia S. Mariasina and Yuri P. Tsentalovich. Animal Metabolite Database: Metabolite Concentrations in Animal Tissues and Convenient Comparison of Quantitative Metabolomic Data. *Metabolites*, **2023**, 13(10), 1088. https://doi.org/10.3390/metabo13101088 .
# About us
<img src="/media/content_files/1/ITC.jpg" alt="ITC SB RAS" height="200px">
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The Animal metabolite database (AMDB) is established at the [Laboratory of Proteomics and Metabolomics](https://www.tomo.nsc.ru/en/structure/lab/lpm/) of the International Tomography Center, Siberian Branch of the Russian Academy of Sciences (ITC SB RAS), and is located in Akademgorodok, Novosibirsk, Russia.
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<td><img src="/media/content_files/1/YP.jpeg" alt="Yuri Tsentalovich" height="150px">
<p>Yuri P. Tsentalovich</p></td>
<td><img src="/media/content_files/1/VY.jpeg" alt="Vadim Yanshole" height="150px">
<p>Vadim V. Yanshole</p></td>
<td><img src="/media/content_files/1/AM.jpeg" alt="Arsenty Melnikov" height="150px">
<p>Arsenty D. Melnikov</p></td>
<td><img src="/media/content_files/1/Lu.jpeg" alt="Lyudmila Yanshole" height="150px">
<p>Lyudmila V. Yanshole</p></td>
<td><img src="/media/content_files/1/EZ.jpeg" alt="Ekaterina Zelentsova" height="150px">
<p>Ekaterina A. Zelentsova</p></td>
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<td><img src="/media/content_files/1/KOA.jpeg" alt="Olga A. Snytnikova" height="150px">
<p>Olga A. Snytnikova</p></td>
<td><img src="/media/content_files/1/NO.jpg" alt="Nataliya A. Osik" height="150px">
<p>Nataliya A. Osik</p></td>
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## Facilities and Instrumentation
The data obtained mainly with the use of Nuclear Magnetic Resonance (**NMR**) spectrometer **Avance III HD 700 MHz** (Bruker Biospin) and with the liquid chromatography with mass spectrometric detection (**LC-MS**) **UltiMate 3000RS** (Dionex) + **maXis 4G** (Bruker Daltonics).
<img src="/media/content_files/1/NMR700.JPG" alt="Avance III HD" height="300px">
<img src="/media/content_files/1/Maxis-Dionex.jpg" alt="Maxis and Dionex" height="300px">
<img src="/media/content_files/1/CryoStar-Eppendorf-2.jpg" alt="Equipment" height="300px">
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## Contributors
Anastasiya A. Khlichkina, Semen O. Tamara, Dr. Kirill A. Sharshov, Alexander A. Sharshov, Svetlana P. Sharshova, Alexander G. Markhaev, Alexey V. Druzyaka, Alexander V. Volkov, Alexander V. Prokudin, Eugene V. Shemyakin, Arina M. Loginova, Albina N. Kanzeparova, Igor A. Iskakov, Valery V. Chernykh, Elena V. Egorova, Anjella Zh. Fursova, Sergei V. Shekhovtsov, Daniil I. Berman, Denis A. Stepakov, Vladimir P. Novoselov, Nataliya G. Kolosova, Elena N. Kozhevnikova, Maryana V. Morozova, Mariya A. Borisova, Kseniya M. Achasova, Ekaterina A. Litvinova, Oyuna S. Kozhevnikova.
### Funding
The AMDB was set up with the financial support from the Russian Foundation for Basic Research (Grant #18-29-13023) and is developing with the financial support from the Russian Scientific Foundation (Grant #22-24-00390)
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<a href="https://www.tomo.nsc.ru/en/structure/lab/lpm/">
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