Rabbit blood and ocular tissues post-mortem

Description:
Comparison of rabbit blood ante-mortem and immediately post-mortem. And post-mortem ocular tissues of rabbit. *Reference*: Ekaterina A. Zelentsova, Lyudmila V. Yanshole, Olga A. Snytnikova, Vadim V. Yanshole, Yuri P. Tsentalovich, Renad Z. Sagdeev. Post-mortem changes in the metabolomic compositions of rabbit blood, aqueous and vitreous humors. (2016). Metabolomics, 12: 172. (DOI:10.1007/s11306-016-1118-2).
Property Value
Experiment name Rabbit blood and ocular tissues post-mortem
Experiment ID 277
Sample groups Rabbit AH PM, Rabbit VH PM, Rabbit blood, Rabbit blood PM
Species European rabbit (Oryctolagus cuniculus)
Tissues Aqueous humor, Blood, Vitreous humor
Diseases N/A
Date of creation 14:27, Jun 30, 2023
Date of last modification 14:38, Jun 30, 2023
Author v.yanshole
Charts:
Concentration table
Average concentrations of metabolites in groups. Average ± Std.Dev., in nmol per gram of wet tissue (nmol/g).
Metabolites / Groups Rabbit AH PM Rabbit VH PM Rabbit blood Rabbit blood PM
2-Hydroxy-3-methylbutyric acid 4.7 ± 5.1 1.2 ± 2.1 3.6 ± 6.2 3.3 ± 5.7
2-Hydroxybutyric acid 7.7 ± 3.2 8.0 ± 2.2 4.6 ± 1.8 9.7 ± 2.7
3-Hydroxybutyric acid 7.7 ± 13.4 0 ± 0 5.5 ± 9.6 31.3 ± 54.3
3-Methyl-2-oxovaleric acid 10.8 ± 2.2 8.8 ± 3.8 11.9 ± 6.5 34.2 ± 23.2
Acetic acid 374.2 ± 244.5 302.2 ± 113.2 326.9 ± 300.0 503.0 ± 195.5
Acetylcarnitine 2.7 ± 3.2 3.2 ± 2.4 2.6 ± 0.7 7.6 ± 2.3
Alanine 334.9 ± 271.4 296.6 ± 192.6 198.5 ± 61.0 413.4 ± 153.4
AMP 0 ± 0 1.6 ± 2.8 0 ± 0 9.4 ± 8.4
Ascorbic acid 345.6 ± 206.7 289.8 ± 57.5 2.5 ± 2.7 9.4 ± 9.2
Asparagine 43.4 ± 34.6 28.0 ± 35.5 39.6 ± 20.8 44.0 ± 10.1
Benzoic acid 5.6 ± 9.8 1.3 ± 2.2 21.6 ± 11.0 20.4 ± 18.4
Betaine 60.5 ± 44.0 50.9 ± 37.4 73.1 ± 27.0 91.0 ± 29.1
Carnitine 7.5 ± 5.2 18.7 ± 18.0 8.7 ± 3.5 19.1 ± 4.3
Choline 13.1 ± 6.4 18.3 ± 8.8 10.7 ± 5.4 23.1 ± 7.5
Citric acid 101.2 ± 96.3 39.0 ± 67.6 46.3 ± 29.8 58.2 ± 23.3
Creatine 79.9 ± 21.8 41.7 ± 23.9 74.6 ± 28.8 140.3 ± 49.9
Creatinine 29.5 ± 17.5 17.9 ± 4.3 43.6 ± 9.7 64.2 ± 9.3
Formic acid 37.9 ± 18.6 31.6 ± 8.5 17.9 ± 1.6 13.9 ± 2.9
Fumaric acid 1.8 ± 0.6 4.4 ± 5.4 0.7 ± 0.6 14.8 ± 6.0
Glucose 4091.8 ± 2074.3 2652.7 ± 853.0 4820.9 ± 539.8 11776.1 ± 7141.9
Glutamic acid 109.3 ± 67.5 324.4 ± 366.1 56.7 ± 15.7 106.0 ± 63.4
Glutamine 417.8 ± 199.3 346.6 ± 58.2 394.0 ± 174.5 473.1 ± 194.9
Glycerol 74.9 ± 3.3 103.3 ± 57.6 73.1 ± 18.6 158.2 ± 36.2
Glycine 301.3 ± 374.9 133.2 ± 107.7 746.3 ± 143.9 865.7 ± 136.8
GSH 0 ± 0 799.7 ± 1281.8 0 ± 0 0 ± 0
Histidine 88.7 ± 71.6 51.0 ± 41.1 67.2 ± 22.4 79.1 ± 22.1
Hypoxanthine 2.6 ± 3.0 2.2 ± 2.0 5.2 ± 5.4 42.7 ± 22.7
Isobutyric acid 12.8 ± 2.2 13.6 ± 3.8 9.7 ± 3.4 12.2 ± 3.4
Isoleucine 45.1 ± 37.4 25.1 ± 16.6 39.7 ± 4.7 56.7 ± 6.8
Ketoleucine 11.5 ± 8.1 8.6 ± 8.3 5.1 ± 0.7 4.2 ± 2.7
Lactic acid 9280.8 ± 1305.8 10956.5 ± 3026.0 4776.1 ± 3466.7 16029.9 ± 1926.9
Leucine 84.9 ± 70.8 100.0 ± 93.2 70.1 ± 6.8 106.0 ± 6.8
Lysine 163.8 ± 121.9 99.7 ± 62.6 76.1 ± 11.8 98.5 ± 27.2
Mannose 32.8 ± 17.0 19.8 ± 4.1 35.1 ± 9.4 47.0 ± 2.2
Methionine 51.2 ± 32.2 47.2 ± 41.3 45.2 ± 26.9 46.6 ± 18.9
myo-Inositol 85.0 ± 37.0 684.9 ± 817.0 38.2 ± 10.4 68.7 ± 9.3
Ornithine 38.7 ± 29.9 22.5 ± 18.1 27.2 ± 7.4 71.6 ± 48.4
Phenylalanine 63.4 ± 50.2 37.9 ± 24.1 40.1 ± 9.0 47.3 ± 7.6
Phosphocholine 5.7 ± 2.8 28.4 ± 40.0 2.5 ± 1.3 6.0 ± 2.4
Propylene glycol 0.3 ± 0.6 0 ± 0 1.5 ± 2.6 1.5 ± 2.6
Pyroglutamic acid 40.4 ± 12.5 122.7 ± 61.8 16.7 ± 9.2 17.2 ± 4.7
Pyruvic acid 154.7 ± 81.7 168.3 ± 80.4 92.5 ± 20.7 71.6 ± 23.7
scyllo-Inositol 9.8 ± 1.8 74.3 ± 86.4 7.8 ± 2.5 10.9 ± 3.6
Serine 241.1 ± 175.3 233.5 ± 148.7 73.1 ± 68.0 83.6 ± 72.9
Succinic acid 16.5 ± 13.2 36.2 ± 39.6 5.5 ± 3.0 258.2 ± 128.7
Taurine 167.4 ± 150.4 233.7 ± 312.9 0 ± 0 0 ± 0
Threonine 107.8 ± 97.7 144.3 ± 167.6 76.1 ± 27.2 83.6 ± 26.2
Tryptophan 23.1 ± 20.8 8.0 ± 13.8 35.8 ± 7.0 29.4 ± 9.9
Tyrosine 110.4 ± 86.3 78.2 ± 52.4 52.2 ± 16.9 64.2 ± 18.6
Uridine 8.6 ± 2.6 5.1 ± 5.2 2.8 ± 4.9 16.7 ± 15.6
Valine 138.9 ± 116.5 78.8 ± 42.3 109.0 ± 10.3 137.3 ± 13.7
Full concentration table
Concentration of metabolites in samples, in nmol per gram of wet tissue (nmol/g).
Metabolites / Samples R1AH1 R2AH1 R3AH1 R1VH1 R2VH1 R3VH1 R1Bl0 R2Bl0 R3Bl0 R1Bl1 R2Bl1 R3Bl1
2-Hydroxy-3-methylbutyric acid 0 10.1 3.9 3.6 0 0 10.8 0 0 9.9 0 0
2-Hydroxybutyric acid 4.2 10.5 8.4 10.2 5.8 7.9 6.7 3.6 3.6 10.3 12.1 6.7
3-Hydroxybutyric acid 23.2 0 0 0 0 0 16.6 0 0 94.0 0 0
3-Methyl-2-oxovaleric acid 8.5 12.7 11.2 10.2 4.5 11.8 19.3 9.9 6.7 53.7 40.3 8.5
Acetic acid 380.2 126.9 615.7 223.9 250.8 432.1 183.6 125.4 671.6 604.5 277.6 626.9
Acetylcarnitine 0.4 6.3 1.4 5.6 0.9 3.1 1.9 3.4 2.5 9.0 4.9 9.0
Alanine 25.3 447.8 531.7 381.6 76.1 432.1 246.3 129.9 219.4 582.1 282.1 376.1
AMP 0 0 0 0 4.9 0 0 0 0 12.1 0 16.1
Ascorbic acid 107.7 447.8 481.3 315.5 223.9 329.9 0 5.4 2.2 0 9.9 18.4
Asparagine 5.3 52.2 72.8 68.7 3.6 11.8 53.7 15.7 49.3 44.8 33.6 53.7
Benzoic acid 16.9 0 0 3.8 0 0 26.9 9.0 29.1 35.8 0 25.5
Betaine 9.9 82.1 89.6 91.6 17.9 43.2 98.5 44.8 76.1 120.9 62.7 89.6
Carnitine 1.5 10.5 10.6 10.4 6.3 39.3 7.6 5.8 12.5 22.8 14.3 20.2
Choline 20.3 7.8 11.2 8.1 22.8 24.0 15.7 4.9 11.6 31.8 18.8 18.8
Citric acid 5.1 197.8 100.8 117.0 0 0 80.6 26.9 31.3 85.1 44.8 44.8
Creatine 54.9 89.6 95.2 68.7 23.3 33.0 53.7 62.7 107.5 103.0 120.9 197.0
Creatinine 9.3 41.0 38.1 19.6 21.0 13.0 34.5 53.7 42.5 53.7 71.6 67.2
Formic acid 16.9 44.8 52.1 33.1 22.4 39.3 18.8 16.1 18.8 10.8 16.6 14.3
Fumaric acid 1.3 1.7 2.5 2.0 0.7 10.6 0.9 0 1.2 21.5 13.0 9.9
Glucose 1753.0 4813.4 5709.0 3409.1 2820.9 1728.2 4880.6 4253.7 5328.4 20014.9 7343.3 7970.2
Glutamic acid 44.4 104.5 179.1 137.4 89.6 746.3 71.6 40.3 58.2 179.1 71.6 67.2
Glutamine 188.0 522.4 542.9 407.1 291.0 341.7 582.1 237.3 362.7 671.6 282.1 465.7
Glycerol 71.8 74.6 78.4 50.9 94.0 165.0 58.2 94.0 67.2 197.0 152.2 125.4
Glycine 23.2 153.0 727.6 40.7 107.5 251.4 806.0 582.1 850.8 895.5 716.4 985.1
GSH 0 0 0 0 120.9 2278.1 0 0 0 0 0 0
Histidine 10.6 104.5 151.1 96.7 17.0 39.3 89.6 44.8 67.2 94.0 53.7 89.6
Hypoxanthine 5.9 1.9 0 3.1 3.6 0 4.9 0 10.8 38.5 22.4 67.2
Isobutyric acid 10.6 14.9 12.9 12.2 17.9 10.6 9.0 13.4 6.7 9.0 15.7 12.1
Isoleucine 4.7 52.2 78.4 40.7 7.6 27.1 34.5 41.2 43.4 58.2 49.3 62.7
Ketoleucine 2.3 14.9 17.4 16.5 9.4 0 4.5 5.8 4.9 1.8 3.6 7.2
Lactic acid 10771.6 8731.3 8339.6 7632.3 11686.6 13550.7 2910.5 2641.8 8776.1 16119.4 14059.7 17910.5
Leucine 10.4 93.3 151.1 71.2 24.6 204.2 62.7 71.6 76.1 111.9 98.5 107.5
Lysine 23.2 238.8 229.5 167.9 44.8 86.4 85.1 62.7 80.6 116.4 67.2 111.9
Mannose 13.3 44.8 40.3 24.2 19.3 16.1 25.5 44.3 35.4 49.3 47.0 44.8
Methionine 15.6 59.7 78.4 94.1 16.1 31.4 76.1 26.9 32.7 67.2 30 42.5
myo-Inositol 122.5 48.5 84.0 63.6 380.6 1610.4 49.3 28.7 36.7 76.1 58.2 71.6
Ornithine 4.2 56.0 56.0 43.3 9.9 14.5 34.0 19.3 28.2 85.1 17.9 111.9
Phenylalanine 5.5 89.6 95.2 63.6 15.7 34.6 49.3 39.9 31.3 39.0 49.3 53.7
Phosphocholine 3.0 8.6 5.6 5.3 5.4 74.6 2.5 1.2 3.9 8.1 3.3 6.7
Propylene glycol 1.0 0 0 0 0 0 4.5 0 0 4.5 0 0
Pyroglutamic acid 54.9 32.8 33.6 173 53.7 141.4 14.3 9.0 26.9 22.4 15.7 13.4
Pyruvic acid 61.3 212.7 190.3 106.9 138.8 259.2 80.6 80.6 116.4 80.6 44.8 89.6
scyllo-Inositol 7.8 10.5 11.2 11.5 38.5 172.8 10.3 5.4 7.6 14.3 7.2 11.2
Serine 42.2 373.1 307.8 279.9 67.2 353.5 0 85.1 134.3 0 116.4 134.3
Succinic acid 31.7 9.3 8.4 0 30 78.6 4.0 9.0 3.6 376.1 277.6 120.9
Taurine 211.2 0 291.0 0 111.9 589.2 0 0 0 0 0 0
Threonine 11.8 104.5 207.1 45.8 49.3 337.8 62.7 58.2 107.5 94.0 53.7 103.0
Tryptophan 3.4 21.3 44.8 23.9 0 0 39.0 27.8 40.8 29.1 19.7 39.4
Tyrosine 12.0 145.5 173.5 132.3 27.8 74.6 71.6 40.3 44.8 85.1 49.3 58.2
Uridine 10.6 5.6 9.5 10.4 4.9 0 0 8.5 0 19.3 30.9 0
Valine 11.8 164.2 240.7 104.3 30 102.1 103.0 103.0 120.9 134.3 125.4 152.2
Metadata
Properties / Samples R1AH1 R2AH1 R3AH1 R1VH1 R2VH1 R3VH1 R1Bl0 R2Bl0 R3Bl0 R1Bl1 R2Bl1 R3Bl1
Group Rabbit AH PM Rabbit AH PM Rabbit AH PM Rabbit VH PM Rabbit VH PM Rabbit VH PM Rabbit blood Rabbit blood Rabbit blood Rabbit blood PM Rabbit blood PM Rabbit blood PM
Description N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Species European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (… European rabbit (…
Tissue Aqueous humor Aqueous humor Aqueous humor Vitreous humor Vitreous humor Vitreous humor Blood Blood Blood Blood Blood Blood
Diseases N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Gender N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Origin laboratory laboratory laboratory laboratory laboratory laboratory laboratory laboratory laboratory laboratory laboratory laboratory
Sample weight, mg N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Sampling place Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS Vivarium of the Institute of Cytology and Genetics SB RAS
Sampling date N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Age, months 3 3 3 3 3 3 3 3 3 3 3 3
Time postmortem, min 10 10 10 10 10 10 N/A N/A N/A 10 10 10
Raw files
File types / Samples R1AH1 R2AH1 R3AH1 R1VH1 R2VH1 R3VH1 R1Bl0 R2Bl0 R3Bl0 R1Bl1 R2Bl1 R3Bl1
MS N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
NMR
N/A N/A N/A
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