Human aqueous humor post-mortem

Description:
Human aqueous humor at different post-mortem intervals. *Reference*: Zelentsova, E.A., Yanshole, L.V., Melnikov, A.D., Kudryavtsev, I.S., Novoselov, V.P., Tsentalovich, Y.P. Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor. Metabolomics 16 (2020) 80. DOI: 10.1007/s11306-020-01700-3
Property Value
Experiment name Human aqueous humor post-mortem
Experiment ID 242
Sample groups Human AH PM
Species Human (Homo sapiens)
Tissues Aqueous humor
Diseases N/A
Date of creation 15:00, Dec 16, 2022
Date of last modification 09:10, Sep 07, 2023
Author y.tsentalovich
Charts:
Concentration table
Average concentrations of metabolites in groups. Average ± Std.Dev., in nmol per gram of wet tissue (nmol/g).
Metabolites / Groups Human AH PM
1-Methylhistidine 34.6 ± 21.1
2-Aminobutyric acid 26.3 ± 14.6
2-Hydroxy-3-methylbutyric acid 109.3 ± 127.7
2-Hydroxybutyric acid 235.7 ± 210.1
2-Hydroxyisobutyric acid 31.9 ± 29.2
3-Hydroxybutyric acid 828.1 ± 1032.2
Acetic acid 268.9 ± 349.9
Acetylcarnitine 37.7 ± 26.3
Ascorbic acid 206.0 ± 177.6
Asparagine 32.0 ± 18.4
beta-Alanine 580.0 ± 229.9
Betaine 392.7 ± 243.0
Choline 92.8 ± 40.4
Citric acid 93.9 ± 47.9
Creatine 249.5 ± 197.0
Creatinine 118.8 ± 94.3
Formic acid 20.3 ± 24.0
Fumaric acid 4.1 ± 2.7
Glutamic acid 220.7 ± 102.9
Glutamine 684.2 ± 180.8
Glycerol 316.2 ± 206.1
Glycerophosphocholine 13.6 ± 10.3
Hypotaurine 101.6 ± 149.5
Hypoxanthine 93.8 ± 42.1
IMP 17.7 ± 7.6
Isoleucine 80.7 ± 22.9
Ketoleucine 226.5 ± 84.1
Lactic acid 27436.6 ± 6291.7
Lysine 145.2 ± 47.7
N-acetyltyrosine 97.0 ± 44.3
Phenylalanine 78.4 ± 41.4
Propylene glycol 82.2 ± 122.6
Pyroglutamic acid 390.9 ± 267.8
Pyruvic acid 21.1 ± 22.5
Sarcosine 21.0 ± 22.5
Succinic acid 311.2 ± 114.5
Threonine 101.1 ± 59.8
Tryptophan 111.9 ± 77.2
UDP glucose 396.1 ± 796.8
UTP 25.6 ± 6.9
Valine 239.3 ± 62.9
Full concentration table
Concentration of metabolites in samples, in nmol per gram of wet tissue (nmol/g).
Metabolites / Samples AH1 AH2 AH3 AH4 AH5 AH6 AH7 AH8 AH10 AH12 AH14 AH15 AH16 AH17 AH19 AH20 AH21 AH22 AH23 AH24 AH25 AH26 AH27 AH28 AH29 AH31 AH32 AH33 AH34 AH35 AH36 AH37 AH38
1-Methylhistidine 70.6 51.8 72.3 80.9 66.9 74.2 48.0 40.6 66.2 24.9 12.6 22.8 9.2 13.1 33.1 21.1 19.2 23.4 14.3 26.3 25.3 15.7 19.2 37.4 53.8 23.4 39.4 34.2 19.7 32.4 12.5 25.3 12.6
2-Aminobutyric acid 62.0 14.8 64.2 32.7 24.8 13.6 8.3 9.5 13.5 7.7 23.7 26.1 24.4 30.4 18.7 35.7 33.3 15.2 16.8 31.7 27.7 14.4 9.3 31.4 35.8 16.4 37.5 47.8 31.5 49.7 28.6 22.2 7.9
2-Hydroxy-3-methylbutyric acid 408.9 22.2 438.5 94.8 16.7 36.5 17.9 45.5 10.4 23.5 87.8 46.6 17.5 38.5 72.8 32.4 24.0 23.4 110.8 38.9 68.3 76.7 3.4 136.1 156.0 250 65.8 426.7 199.9 142.0 377.0 50.1 46.7
2-Hydroxybutyric acid 669.1 40.7 827.6 286.1 65.6 86.5 24.0 103.4 51.5 80.2 258.5 214.1 91.6 134.9 332.3 66.1 96.6 110.9 205.3 105.9 193.1 393.6 22.4 409.6 533.2 145.7 173.9 745.1 314.9 412.5 271.3 267.4 44.2
2-Hydroxyisobutyric acid 39.7 12.3 54.4 22.9 17.0 22.6 15.1 18.5 9.5 8.7 11.9 34.4 13.7 17.5 21.2 9.8 13.1 19.7 18.2 13.6 16.2 23.5 5.6 69.9 70.1 27.7 68.2 119.0 62.0 120.6 30.4 30.2 16
3-Hydroxybutyric acid 991.2 45.7 186.5 2877.4 104.6 86.5 48.0 67.7 58.8 78.3 146.9 113.4 47.3 248.9 477.0 60.0 58.6 83.8 1670.0 93.3 1365.3 1543.6 31.7 1124.6 2388.0 709.2 1470.9 3125 2500.5 284.6 3530.6 1269.5 440.5
Acetic acid 109.7 64.2 58.7 85.8 89.2 1149.3 103.4 726.2 64.3 715.1 1593.8 127.2 177.1 140.7 153.0 170.5 259.5 183.3 243.5 129.6 141.5 118.4 80.6 46.0 71.4 839.7 74.2 87 345.1 135.3 352.8 92.5 147.0
Acetylcarnitine 80.5 17.5 66.9 22.6 32.0 33.0 24.4 13.3 33.5 17.7 13.5 90.3 20.2 25.6 47.7 27.5 36.6 42.8 28.9 63.6 17.3 20.9 17.1 113.9 12.9 25.4 53.4 63.4 37.2 91.5 28.8 13.1 12.5
Ascorbic acid 63.2 100.0 119.5 210.9 224.8 815.7 720.4 304.6 634 129.1 74.1 168.2 153.0 145.2 205.2 184.6 237.3 188.4 219.4 210.8 132.7 133.4 92.4 160.4 207.0 225.4 131.7 173.3 95.1 138.6 80.1 61.7 59.5
Asparagine 37.2 25.9 33.4 28.2 22.3 36.2 31.4 24.9 34.9 10.9 35.0 61.4 36.4 30.6 27.3 43.2 82.6 8.9 8.8 56.1 0.3 23.3 3.8 49.2 40.4 31.3 41.4 71.1 28.9 43.1 26.0 12.0 11.1
beta-Alanine 848.7 524.4 623.8 433.2 619.2 438.7 467.9 307.7 643.2 287.0 299.3 742.6 586.7 455.6 698.0 636.3 828.0 866.2 329.0 1060.3 462.5 565.1 340.6 725.0 590.6 591.5 807.4 663.5 365.0 1261.1 294.8 425.1 350.8
Betaine 362.4 157.3 95.4 253.8 173.7 144.6 181.0 71.1 358.4 188.3 222.8 744.1 244.2 259.4 381.0 422.3 611.6 833.2 504.4 1085.1 360.9 728.2 432.9 552.5 252.4 505.9 650.9 247.5 346.4 815.6 260.3 270.2 239.9
Choline 138.4 57.6 39.9 74.9 101.1 70.0 112.9 36.5 85.8 56.9 73.0 136.4 81.2 83.7 162.8 148.2 145.8 93.3 182.0 116.0 73.4 64.7 34.0 49.6 33.6 129.0 113.5 125.1 61.2 154.4 68.5 73.4 85.3
Citric acid 139.4 92.5 139.0 245.2 130.0 120.5 147.8 96.9 101.1 27.3 54.3 111.0 117.7 65.2 63.8 112.6 103.5 41.0 87.4 72.8 31.6 49.2 42.6 169.2 85 167.3 60.2 101.2 84.8 110.4 35.4 56.0 38.1
Creatine 715.5 81.4 170.5 60.1 142.1 69.5 112.7 84.9 139.7 137.6 121.6 580 78.8 98.9 444.1 189.5 202.8 318.3 378.9 592.3 252.7 190.1 83.7 254.8 243.7 160.7 361.5 385.6 130.5 867.2 254.5 177.6 152.1
Creatinine 200.1 45.0 302.6 72.8 57.6 64.9 54.8 41.9 72.9 49.0 36.6 324.3 47.4 105.4 198.7 51.2 75.6 105.8 264.9 95.8 89.1 139.1 45.2 366.7 114.5 53.3 193.8 286.7 74.0 143.9 66.7 47.4 33.3
Formic acid 16.7 5.6 11.1 17.2 14.9 144.6 14.8 7.4 7.4 12.7 15.6 9.2 16.3 13.1 14.9 19.5 19.3 26.3 53.0 12.1 21.3 14.1 11.3 5.8 11.3 23.4 13.7 26.4 26.2 25.0 7.5 15.1 18.8
Fumaric acid 5.2 2.5 1.3 3.8 3.5 2.7 3.1 1.3 4.5 3.2 2.6 8.5 1.7 5.3 6.1 4.8 15.6 3.1 5.4 5.8 0.9 3.7 3.1 4.6 4.4 5.7 4.7 2.3 3.8 6.5 2.1 1.5 1.7
Glutamic acid 455.3 194.3 129.7 245.2 204.3 157.6 166.2 147.7 229.7 136.4 188.2 344.3 121.7 150.2 379.7 297.0 357.4 294.6 367.2 400.6 181.9 300.2 96.5 144.9 61.2 252.0 222.4 212.5 146.5 351.3 100.1 87.9 159.7
Glutamine 910.7 657.1 1000.5 956.4 575.9 658.1 628.0 636.9 661.6 528.7 522.7 828.0 636.1 467.8 655.0 645.9 781.7 717.1 595.5 762.5 529.8 970.6 454.3 757.9 605.5 909.2 722.8 1140.3 554.8 756.1 425.3 325.4 601.8
Glycerol 734.1 490.5 368.7 613.1 548.0 528.3 387.9 692.3 955.6 107.0 110.7 274.7 132.3 171.3 313.3 258.9 276.6 233.7 297.7 360.4 202.2 206.3 77.2 144.9 179.4 239.5 265.1 334.7 156.3 324.2 203.9 119.1 125.5
Glycerophosphocholine 10.3 5.1 12.8 6.8 6.6 11.3 11.7 6.6 9.2 7.4 8.0 24.6 10.3 6.6 11.2 13.3 23.0 39.0 21.6 54.5 14.5 12.4 10.3 13.4 4.3 10.5 18.3 8.0 14.5 23.4 4.1 7.4 7.8
Hypotaurine 762 222.1 222.3 245.2 222.9 259.5 203.2 120 312.4 17.8 23.3 27.3 29.0 30.1 25.3 33.3 49.8 38.5 119.7 46.4 10.4 20.4 12.1 8.2 2.9 25.5 15.3 20.9 21.9 112.8 66.1 18.6 7.0
Hypoxanthine 105.9 57.4 40.8 56.4 79.9 68.6 88.7 46.2 91.9 80.5 81.1 107.7 68.6 95.1 109.1 118.8 116.7 182.8 125.8 215.7 58.5 80.4 46.7 47.7 47.1 122.8 108 66.0 63.1 193.2 109.6 96.3 118.4
IMP 16.5 15.2 11.5 16.9 18.6 16.9 13.1 10.2 16.5 9.5 18.5 35.0 8.0 32.7 14.1 17.7 14.3 20.0 14.3 27.7 15.5 9.0 15.1 16.4 11.2 21.8 41.0 15.2 16.0 30.9 14.9 13.7 16.5
Isoleucine 121.4 63.6 102.5 75.2 60.1 64.3 65.9 84.9 52.1 68.6 88.4 78.1 47.2 44.7 109.2 90.4 97.9 117.1 67.2 135.5 78.9 82.5 58.1 79.0 121.3 93.3 97.5 53.6 84.0 85.6 57.5 67.8 69.1
Ketoleucine 309.8 138.8 318.1 233.0 114.6 154.5 107.8 181.5 131.7 147.1 232.2 231.1 115.5 141.4 240.5 182.5 215.7 257.2 196.8 296.8 216.9 226.7 144.5 258.1 387.8 362.0 248.1 413.3 296.8 279.9 372.3 164.1 156.4
Lactic acid 35256.6 27837.5 25148.7 32893.7 24377.7 27064.9 23839.9 18061.5 31356.8 25690.3 18160.8 26651.0 26467.6 26276.9 24526.6 20343.6 27845.6 33655.0 11888.9 36624.4 24565.6 33698.0 20696.3 30431.7 39231.8 31292.8 36066 27014.0 25919.3 39118.9 27545.4 26019.2 19842.0
Lysine 189.6 153.6 209.4 191.3 152.3 126.1 138.5 55.4 141.5 108.9 107.4 235.6 133.4 118.5 152.3 121.0 176.0 194.1 159.6 219.2 111 168.4 73.4 174.9 99.8 176.9 154.7 134.7 98.9 251.3 108.3 83.1 74.2
N-acetyltyrosine 124.5 93.5 130.6 93.2 76.2 135.3 85.9 56.3 71.7 58.2 59.2 146.2 55.2 58.7 111.4 92.5 104.2 117.8 68.9 89.8 84.5 150.9 55.5 101.7 111.5 103.1 119.1 266.0 66.1 163.2 39.3 59.8 49.9
Phenylalanine 180.3 84.2 171.4 132.4 89.2 180.7 116.4 87.7 79.0 37.1 29.6 97.9 40.2 33.4 49.0 50.5 62.9 72.7 47.2 97.3 44.7 57.0 43.1 68.7 51.5 79.4 94.1 101.1 41.7 102.8 84.4 33.3 45.9
Propylene glycol 26.0 5.7 15.4 85.8 7.4 39.6 20.9 186.5 6.1 53.2 166.1 428.2 8.6 17.8 35.4 25.4 32.7 28.4 30.7 29.5 24.9 53.1 5.6 36.2 35.6 224.2 52.9 42.4 15.0 75.3 559.7 140.0 199.2
Pyroglutamic acid 74.3 65.9 88.9 29.4 42.4 37.1 42.1 55.4 39.7 694.9 643.7 617.8 338.8 430.2 660.7 433.7 614.8 807.7 471.4 1000.3 404.6 411.8 255.9 467.7 367.6 609.1 669.5 186.2 347.3 813.8 383.8 411.6 380.4
Pyruvic acid 45.8 12.3 76.6 66.2 6.8 12.4 56.0 17.9 13.5 4.8 3.4 17.6 12.0 4.0 5.9 7.6 13.5 22.6 4.5 12.0 3.5 11.4 3.5 42.0 90.2 33.7 15.2 35.1 11.3 6.1 10.0 12.4 5.2
Sarcosine 45.2 8.0 30.9 15.5 7.4 10.5 7.4 6.0 8.6 6.6 2.5 113.4 7.6 25.4 17.4 2.9 14.7 8.8 36.3 10.4 20.9 26.7 4.8 54.5 22.5 4.7 41.0 53.8 12.9 42.2 10.4 8.0 4.5
Succinic acid 539.0 263.8 106.5 502.7 320.4 217.8 277.1 115.4 459.4 180.9 130.6 249.1 233.3 275.8 412.2 277.1 309.0 335.9 388.8 420.3 380.6 398.5 142.4 227.1 316.3 396.2 449.3 316.5 234.6 382.0 468.4 351.1 190.5
Threonine 223.0 148.1 203.8 230.5 161.6 165.0 175.5 90.5 178.3 57.7 18.1 42.3 171.2 92.9 84.1 119.6 134.8 76.8 63.4 121.4 39.1 70.8 115.0 51.4 100.5 57.2 62.1 61.9 36.2 53.6 63.9 28.8 38.2
Tryptophan 40.9 22.2 46.3 36.8 24.2 48.2 24.0 18.5 31.2 55.1 43.2 307.6 60.3 132.0 177.8 85.1 102.8 117.5 181.2 117.1 206.1 256.2 87.3 208.4 174.2 95.5 193.5 245.0 103.3 173.9 94.2 107.6 76.2
UDP glucose 0 151.8 4650.5 740.6 0 163.1 27.7 539.1 227.9 291.1 298.5 699.3 276.6 154.4 45.2 253.8 706.8 579.2 25.2 178.7 14.9 73.8 232.6 151.9 155.0 319.0 578.3 5.0 164.6 212.7 101.4 677.5 375.6
UTP 33.5 22.2 33.4 34.3 33.4 31.5 24.0 25.9 33.1 17.8 20.7 35.5 15.8 29.8 19.8 17.5 21.7 19.0 24.4 21.3 18.0 12.2 24.8 22.3 34.4 28.7 36.5 26.5 19.2 38.0 24.1 21.6 22.8
Valine 353.1 209.8 339.7 237.1 222.9 179.2 190.9 203.1 183.8 163.2 239.4 247.9 156.9 154.8 237.0 232.9 266.7 300.8 170.9 308.2 245.4 204.9 168.6 244.2 404.1 313.6 306.2 287.0 280.1 265.6 245.1 171.5 163.5
Metadata
Properties / Samples AH1 AH2 AH3 AH4 AH5 AH6 AH7 AH8 AH10 AH12 AH14 AH15 AH16 AH17 AH19 AH20 AH21 AH22 AH23 AH24 AH25 AH26 AH27 AH28 AH29 AH31 AH32 AH33 AH34 AH35 AH36 AH37 AH38
Group Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM Human AH PM
Description N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Species Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie…
Tissue Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor
Diseases N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Gender N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Origin N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Sample weight, mg 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0 200.0
Sampling place Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia
Sampling date N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Time postmortem, min 2460 1440 300 930 840 780 840 600 1260 750 978 1758 1134 1482 1380 1500 1500 1584 1974 1038 936 660 792 558 342 1590 1692 642 1092 3516 1920 1830 630
Raw files
File types / Samples AH1 AH2 AH3 AH4 AH5 AH6 AH7 AH8 AH10 AH12 AH14 AH15 AH16 AH17 AH19 AH20 AH21 AH22 AH23 AH24 AH25 AH26 AH27 AH28 AH29 AH31 AH32 AH33 AH34 AH35 AH36 AH37 AH38
MS N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
NMR
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