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y.tsentalovich

Yuri Tsentalovich

Email: yura@tomo.nsc.ru

Experiments:

Siberian wood frog hypoxia and normal

Comparison of metabolomic compositions of heart and liver from Siberian wood frog under normal conditions and hypoxia (Siberia, Russia). *Reference*: Sergei V. Shekhovtsov, Nina A. Bulakhova, Yuri P. Tsentalovich, Ekaterina A. Zelentsova, Lyudmila V. Yanshole, Ekaterina N. Meshcheryakova, Daniil I. Berman. Metabolic response of the Siberian wood frog Rana amurensis to anoxia. Sci. Reports 10 (2020) 14604. [DOI: 10.1038/s41598-020-71616-4](https://doi.org/10.1038/s41598-020-71616-4)

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Siberian roe lens

Lenses from Siberian roe deer *Unpublished*

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Mink lens

Lenses from farmed mink from Common Use Center for Gene Pools of Fur and Farm Animals (ICG SB RAS, Novosibirsk, Russia) *Unpublished*

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Rat brain 0.6m 18m

Brains from two laboratory rat strains - Wistar and OXYS (ICG SB RAS, Novosibirsk) *Unpublished*

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Rat lens

Laboratory rat lens (Wistar strain). *Reference*: Vadim V. Yanshole, Olga A. Snytnikova, Alexey S. Kiryutin, Lyudmila V. Yanshole, Renad Z. Sagdeev, Yuri P. Tsentalovich. Metabolomics of the rat lens: a combined LC-MS and NMR study. Exp. Eye Res. 125 (2014) 71-78.

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Rat blood (Autophagy)

Autophagy modulation experiment on 4 month old OXYS and Wistar rats using serum blood Reference: Snytnikova, O.; Tsentalovich, Y.; Sagdeev, R.; Kolosova, N.; Kozhevnikova, O. Quantitative Metabolomic Analysis of Changes in the Rat Blood Serum during Autophagy Modulation: A Focus on Accelerated Senescence. Int. J. Mol. Sci. 2022, 23, 12720. https://doi.org/10.3390/ijms232112720

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Wild and farmed fox lens

Comparison of lenses from wild Red Fox and its farmed melanistic (morph) form Silver Fox *Unpublished*

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11 types of Pike-perch tissues

Metabolomic compositions of 11 tissues from pike-perch, including gill, heart, liver, kidney, spleen, muscle, brain, milt, lens, aqueous (AH) and vitreous (VH) humors. *Reference*: Yu.P. Tsentalovich, E.A. Zelentsova, L.V. Yanshole, V.V. Yanshole, I.M. Odud. Most abundant metabolites in tissues of freshwater fish pike-perch (Sander lucioperca). Sci. Reports 10 (2020) 17128. [DOI: 10.1038/s41598-020-73895-3](https://doi.org/10.1038/s41598-020-73895-3)

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Human cornea and aqueous humour (keratoconus)

Comparison of metabolomic compositions of human cornea and aqueous humor (AH) taken from keratoconus patients and normal post-mortem donors *Reference*: O.A. Snytnikova, L.V. Yanshole, I.A. Iskakov, V.V. Yanshole, V.V. Chernykh, D.A. Stepakov, V.P. Novoselov, Yu.P. Tsentalovich, Quantitative metabolomic analysis of the human cornea and aqueous humor, Metabolomics (2017) 13:152. DOI 10.1007/s11306-017-1281-0

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Pike-perch and roach - seasonal variations

Metabolomic compositions of lenses and gills from pike-perch and Siberian roach caught in Ob reservoir at late autumn and late winter. *Reference*: Yu.P. Tsentalovich, V.V. Yanshole, L.V. Yanshole, E.A. Zelentsova, A.D. Melnikov and R.Z. Sagdeev. Seasonal variations and interspecific differences in metabolomes of freshwater fish tissues: quantitative metabolomic profiles of lenses and gills. Metabolites 2019, 9, 264; [doi:10.3390/metabo9110264](https://doi.org/10.3390/metabo9110264)

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Lenses from 14 bird species

Lenses from various wild birds. *Reference*: Ekaterina A. Zelentsova, Lyudmila V. Yanshole, Yuri P. Tsentalovich, Kirill A. Sharshov and Vadim. V. Yanshole. Application of Quantitative Metabolomics for Taxonomic Differentiation of Birds. Biology 2022, 11, 1089. https://doi.org/10.3390/biology11071089

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Mucine mouse blood

Blood from Mucine2 knockout mouse Muc2-/-, Muc2+/+ and wild type C57Bl/6. *Reference*: Morozova, M.V., Borisova, M.A., Snytnikova, O.A, Achasova K.M., Litvinova E.A., Tsentalovich Y.P., Kozhevnikova E.N. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. Sci Rep 12, 16345 (2022). https://doi.org/10.1038/s41598-022-19219-z

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Porcine lens

Lens from farm porcine, intact lens and UVA irradiated. *Unpublished*

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Three gull species lenses

lenses from three gull species *Reference*: N.A. Osik, E.A. Zelentsova, K.A. Sharshov, Yu.P. Tsentalovich. Nicotinamide adenine dinucleotide reduced (NADH) is a natural UV flter of certain bird lens. Scientific Reports (2022) 12(1), 16850. https://doi.org/10.1038/s41598-022-21139-x

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Rat brain incubation

Incubation of rat brain extracts and homogenates at 4 C for examining the stability of metabolomic content during sample preparation for metabolomics experiments *Reference*: Fomenko M.V., Yanshole L.V., Tsentalovich Y.P.. Stability of Metabolomic Content during Sample Preparation: Blood and Brain Tissues. Metabolites. 2022; 12(9):811. https://doi.org/10.3390/metabo12090811

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Perch lens from Borovoye, Nigiya, Ob reservoir

Comparison of metabolomic compositions of lenses from perch caught in March 2019 in lake Borovoye, river Nigiya and in Ob reservoir (Siberia, Russia). *Reference*: Tsentalovich, Y.P.; Zelentsova, E.A.; Savina, E.D.; Yanshole, V.V.; Sagdeev, R.Z. Influence of Ecological Factors on the Metabolomic Composition of Fish Lenses. Biology 2022, 11, 1709. https://doi.org/10.3390/biology11121709

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Mice brain with phospholipids treatment

Brain from C57Bl/6 mice after long term phospholipids treatment. Reference: unpublished

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Cow lens

Fresh cow lenses. Reference: unpublished

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Mice blood with phospholipids treatment

Blood serum from C57Bl/6 mice after long term phospholipids treatment. Reference: unpublished

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Predator and waterfowl bird lenses

Lenses from various wild predator and waterfowl birds

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Human vitreous humor post-mortem

Human vitreous humor at different post-mortem intervals. *Reference*: Zelentsova, E.A., Yanshole, L.V., Melnikov, A.D., Kudryavtsev, I.S., Novoselov, V.P., Tsentalovich, Y.P. Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor. Metabolomics 16 (2020) 80. DOI: 10.1007/s11306-020-01700-3

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Human blood post-mortem

Human blood at different post-mortem intervals. Reference: Zelentsova, E.A., Yanshole, L.V., Melnikov, A.D., Kudryavtsev, I.S., Novoselov, V.P., Tsentalovich, Y.P. Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor. Metabolomics 16 (2020) 80. DOI: 10.1007/s11306-020-01700-3

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Rat brain 3 months

Brains from two laboratory rat strains - Wistar and OXYS (ICG SB RAS, Novosibirsk) Reference: unpublished

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Frozen worms

Metabolome of two types of worms (Dendrobaena octaedra, Eisenia sp. aff. nordenskioldi f. pallida) in cold (+1 C) and frozen (-8 C) conditions

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Salamander frozen and normal

Comparison of metabolomic compositions of liver and muscle from Siberian salamander under normal conditions and frozen at -8C. Reference:

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Ruffe lens from Nigiya and Ob reservoir

Comparison of metabolomic compositions of lenses from Eurasian ruffe (Gymnocephalus cernua) caught in March 2019 in river Nigiya and in Ob reservoir (Siberia, Russia). *Publication*: Tsentalovich, Y.P.; Zelentsova, E.A.; Savina, E.D.; Yanshole, V.V.; Sagdeev, R.Z. Influence of Ecological Factors on the Metabolomic Composition of Fish Lenses. Biology 2022, 11, 1709. https://doi.org/10.3390/biology11121709

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Mucine mouse brain

Brain from Mucine2 knockout mouse Muc2-/-, Muc2+/+ and wild type C57Bl/6. *Reference*: Morozova, M.V., Borisova, M.A., Snytnikova, O.A, Achasova K.M., Litvinova E.A., Tsentalovich Y.P., Kozhevnikova E.N. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. Sci Rep 12, 16345 (2022). https://doi.org/10.1038/s41598-022-19219-z

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Human blood incubation

Incubation of human blood extracts and homogenates at 4 C for examining the stability of metabolomic content during sample preparation for metabolomics experiments Reference: Fomenko M.V., Yanshole L.V., Tsentalovich Y.P.. Stability of Metabolomic Content during Sample Preparation: Blood and Brain Tissues. Metabolites. 2022; 12(9):811. https://doi.org/10.3390/metabo12090811

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Macaque ocular tissues and blood

Serum, aqueous humor, lens, and vitreous humor of crab-eating macaque

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Human aqueous humor post-mortem

Human aqueous humor at different post-mortem intervals. *Reference*: Zelentsova, E.A., Yanshole, L.V., Melnikov, A.D., Kudryavtsev, I.S., Novoselov, V.P., Tsentalovich, Y.P. Post-mortem changes in metabolomic profiles of human serum, aqueous humor and vitreous humor. Metabolomics 16 (2020) 80. DOI: 10.1007/s11306-020-01700-3

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Frozen frog - liver

Liver from frozen and control moor frog Rana arvalis. *Reference*: S.V. Shekhovtsov, N.A. Bulakhova, Yu.P. Tsentalovich, E.A. Zelentsova, E.N. Meshcheryakova, T.V. Poluboyarova, D.I. Berman. Metabolomic analysis reveals that the moor frog Rana arvalis uses both glucose and glycerol as cryoprotectants. Animals 2022, 12, 1286. https://doi.org/10.3390/ani12101286

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Far Eastern frog hypoxia

Far Eastern frog heart, liver, brain

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Macaque rhesus and crab-eating

Aqueous humor, lens, and vitreous humor of rhesus crab-eating macaque

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Sample groups:

C.aeruginosus lens

Lenses of Western marsh harrier (Circus aeruginosus)

y.tsentalovich

Experiments:

Siberian wood frog hypoxia and normal

Siberian roe lens

Mink lens

Rat brain 0.6m 18m

Rat lens

Rat blood (Autophagy)

Wild and farmed fox lens

11 types of Pike-perch tissues

Human cornea and aqueous humour (keratoconus)

Pike-perch and roach - seasonal variations

Lenses from 14 bird species

Mucine mouse blood

Porcine lens

Three gull species lenses

Rat brain incubation

Perch lens from Borovoye, Nigiya, Ob reservoir

Mice brain with phospholipids treatment

Cow lens

Mice blood with phospholipids treatment

Predator and waterfowl bird lenses

Human vitreous humor post-mortem

Human blood post-mortem

Rat brain 3 months

Frozen worms

Salamander frozen and normal

Ruffe lens from Nigiya and Ob reservoir

Mucine mouse brain

Human blood incubation

Macaque ocular tissues and blood

Human aqueous humor post-mortem

Frozen frog - liver

Far Eastern frog hypoxia

Macaque rhesus and crab-eating

Sample groups:

C.aeruginosus lens

L.excubitor lens

Macaque AH

P.grisegena lens

Macaque VH

Macaque Lens

Fox lens (wild)

C.frugilegus lens

Wistar brain 18m

Porcine lens intact

OXYS rat brain 20d

Porcine lens irr

Frog Liver hypoxia

Frog Heart normoxia

Perch lens Nigiya

Perch lens Ob

Pike-perch spleen

Pike-perch VH

Pike-perch AH

Pike-perch brain

Pike-perch gill

Pike-perch kidney

Pike-perch heart

Pike-perch lens

Pike-perch milt

Pike-perch muscle

Pike-perch lens autumn

Pike-perch lens winter

Roach gill winter

Roach lens autumn

P.cristatus lens

C. coccothraustes lens

M.migrans lens

E.Godlewskii lens

P.pica lens

P.domesticus lens

C.cornix lens

C57BL/6 blood

C57BL/6 blood Muc2-

C57BL/6 brain

C57BL/6 brain Muc2-

C57BL/6 brain Muc2+

Wistar lens 3m

L.argentatus lens