| Property | Value |
|---|---|
| Group name | Human lens cataract |
| Group ID | 678 |
| Related experiment | Human lens and AH. Cataractous and normal |
| Samples | CatLens1-5c, CatLens2-6c, CatLens3-8c, CatLens4-9c, CatLens5-10c, CatLens6-11c, CatLens7-12c, CatLens8-13c, CatLens9-l4, CatLens10-l18, CatLens11-l24, CatLens12-l25 |
| Species | Human (Homo sapiens) |
| Tissues | Lens |
| Diseases | COPD, Cataract, Glaucoma, HTN |
| Date of creation | Jun 30, 2023 |
| Date of last modification | Sep 07, 2023 |
| Metabolites / Samples | CatLens1-5c | CatLens2-6c | CatLens3-8c | CatLens4-9c | CatLens5-10c | CatLens6-11c | CatLens7-12c | CatLens8-13c | CatLens9-l4 | CatLens10-l18 | CatLens11-l24 | CatLens12-l25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-Hydroxy-3-methylbutyric acid | 0 | 8.9 | 154.9 | 8.3 | 5.8 | 29.1 | 0 | 15.9 | 15.5 | 15.0 | 6.6 | 18.1 |
| 2-Hydroxybutyric acid | 0 | 6.8 | 0 | 13.7 | 11.1 | 0 | 0 | 3.0 | 7.4 | 5.3 | 14.2 | 10.1 |
| 3-Hydroxybutyric acid | 0 | 5.7 | 0 | 8.3 | 5.8 | 0 | 0 | 7.4 | N/A | N/A | N/A | N/A |
| 3-Hydroxykynurenine | 2.7 | 0.6 | 1.6 | 0.9 | 0.7 | 0.8 | 3.3 | 5.4 | 16.9 | 4.4 | 2.3 | 11.6 |
| 3-Methyl-2-oxovaleric acid | 0 | 3.9 | 0 | 2.9 | 3.4 | 0 | 0 | 1.5 | 3.7 | 0.7 | 3.3 | 4.8 |
| 3-OH-CKA-G | 0.6 | 0 | 0 | 0 | 0.4 | 0 | 0.6 | 0 | 0 | 1.3 | 3.2 | 0 |
| 3-OHKDG | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.0 | 0 | 0 | 3.7 |
| 3-OHKG | 82.6 | 10.7 | 62.0 | 19.8 | 9.4 | 69.8 | 57.0 | 212.2 | 566.2 | 90.7 | 49.4 | 742.6 |
| 4-Aminobutyric acid | 22.6 | 2.5 | 44.4 | 1.5 | 0.6 | 122.3 | 16.8 | 21.9 | 162.5 | 8.5 | 0 | 139.6 |
| Acetic acid | 747.6 | 3417.4 | 1174.9 | 1367.7 | 417.8 | 423.4 | 403.8 | 843.9 | 2203.0 | 1179.1 | 350.6 | 1327.6 |
| Acetylcarnitine | 5.0 | 0.8 | 10.5 | 0.9 | 1.7 | 9.2 | 5.7 | 8.6 | 18.8 | 5.6 | 4.0 | 20.4 |
| Adenosine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 1.2 | 1.0 | 1.0 | 2.5 |
| Adenosylhomocysteine | 36.3 | 2.0 | 47.3 | 2.0 | 1.2 | 72.9 | 17.6 | 51.7 | 118.3 | 17.2 | 2.0 | 195.5 |
| ADP | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 45.8 | 1.8 | 0 | 152.9 |
| AHBDG | 0.4 | 0 | 1.0 | 0 | 0 | 0.6 | 0.6 | 0.4 | 3.1 | 0 | 0 | 6.8 |
| AHBG | 17.3 | 0.4 | 27.5 | 3.4 | 0.5 | 26.2 | 14.4 | 39.0 | 145.6 | 26 | 5.5 | 144.0 |
| Alanine | 613.2 | 167.3 | 1316.9 | 153.3 | 144.1 | 873.3 | 822.0 | 766.1 | 864.1 | 389.1 | 331.7 | 663.8 |
| Alanylalanine | 0.7 | 0.3 | 0.2 | 1.0 | 0.1 | 1.4 | 0.1 | 1.6 | N/A | N/A | N/A | N/A |
| AMP | 0 | 0 | 0 | 12.4 | 0 | 22.5 | 0 | 10.7 | 71.5 | 13.6 | 5.7 | 148.9 |
| Arginine | 28.0 | 21.5 | 43.9 | 21.9 | 28.5 | 29.7 | 34.5 | 16.0 | 24.2 | 42.1 | 15.9 | 32.8 |
| Ascorbic acid | 147.9 | 32.0 | 387.3 | 145.1 | 5.8 | 211.7 | 201.9 | 251.7 | 329.0 | 117.9 | 151.6 | 470.7 |
| Asparagine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 86.1 | 40.5 | 34.3 | 109.4 |
| Aspartic acid | 19.9 | 37.6 | 21.7 | 15.4 | 16.3 | 17.7 | 29.7 | 13.2 | 26.4 | 25.5 | 12.3 | 10.8 |
| ATP | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 7.4 | 0 | 0 | 34.9 |
| Benzoic acid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.9 | 62.9 | 61.9 | 90.0 | 80.5 |
| Betaine | 3.0 | 3.6 | 5.2 | 0.1 | 3.2 | 3.4 | 4.0 | 0.1 | 1.1 | 2.6 | 2.5 | 0.7 |
| Carnitine | 28.2 | 5.7 | 62.0 | 5.4 | 9.6 | 47.6 | 26.0 | 40.7 | 68.7 | 13.9 | 7.6 | 68.4 |
| Choline | 6.6 | 8.5 | 0 | 5.4 | 7.2 | 5.6 | 8.1 | 10.7 | 7.4 | 19.8 | 9.5 | 11.7 |
| Citric acid | 0 | 462.8 | 0 | 136.8 | 52.8 | 0 | 0 | 51.8 | N/A | 50.1 | N/A | N/A |
| CMP | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2.9 | 0.8 | 0.6 | 4.6 |
| Creatine | 605.1 | 35.6 | 1162.0 | 91.2 | 76.8 | 1058.5 | 432.6 | 703.2 | 1173.1 | 191.6 | 113.7 | 2212.7 |
| Creatinine | 37.7 | 16.7 | 93.0 | 17.8 | 52.8 | 92.6 | 46.2 | 55.5 | 77.3 | 29.5 | 16.1 | 132.8 |
| Cys-3-OHKG | 0.9 | 0 | 0.7 | 0.8 | 0 | 0 | 2.2 | 1.5 | 2.8 | 3.4 | 2.9 | 0 |
| Cystathionine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 5.2 | 0.1 | 0 | 0.8 |
| Cystine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 0.7 | 6.5 | 5.3 | 0 |
| Cytidine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 0 | 0 | 0 |
| Formic acid | 78.0 | 92.6 | 129.1 | 78.7 | 96.1 | 52.9 | 113.9 | 92.5 | 68.7 | 59.0 | 118.5 | 80.5 |
| Fumaric acid | 0 | 1.1 | 0 | 0 | 1.4 | 0 | 0 | 0 | 0 | 0.6 | 0.5 | 0.3 |
| Glucose | 0 | 676.4 | 245.3 | 700.4 | 955.7 | 158.8 | 187.5 | 88.8 | 200.3 | 374.4 | 1753.1 | 438.5 |
| Glutamic acid | 930.0 | 133.0 | 1944.3 | 178.1 | 55.7 | 1497.4 | 513.9 | 1154.3 | 1001.0 | 451.5 | 109.2 | 1248.7 |
| Glutamine | 695.2 | 259.9 | 1342.8 | 248.7 | 273.7 | 886.5 | 749.9 | 1014.1 | 915.6 | 495.2 | 331.7 | 965.5 |
| Glycerol | 107.6 | 320.4 | 697.2 | 207.2 | 293.0 | 317.6 | 548.0 | 481.1 | 274.7 | 64.9 | 80.6 | 92.5 |
| Glycine | 161.4 | 85.4 | 284.1 | N/A | 38.4 | 198.5 | 245.2 | 177.7 | 211.7 | 85.5 | 14.2 | 201.2 |
| GMP | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 19.8 | 4.7 | 2.4 | 28.5 |
| GSH | 714.5 | 3.9 | 1804.3 | 237.7 | 5.0 | 1517 | 41.4 | 1814.0 | 672.8 | 98.3 | 4.1 | 1325.6 |
| GSH-3-OHKG | 14.2 | 0 | 10.6 | 3.1 | 0.8 | 8.9 | 4.6 | 33.6 | 82.4 | 23.5 | 11.7 | 32.7 |
| GSH-3-OHKN | 0 | 0 | 0.5 | 0 | 0 | 0 | 0 | 0 | 0.8 | 0 | 0 | 0 |
| GSH-KN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.2 | 1.4 | 0 | 0 | 0 |
| GSSG | 117.1 | 7.1 | 188.5 | 24.9 | 22.3 | 107.3 | 40.6 | 69.3 | 55.8 | 37.4 | 15.8 | 107.3 |
| Guanine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 2.5 | 1.8 | 2.0 | 4.5 |
| Guanosine | 4.2 | 0.9 | 12.9 | 2.1 | 0.6 | 8.9 | 7.5 | 7.1 | 5.1 | 2.6 | 3.1 | 5.7 |
| Histidine | 129.1 | 42.7 | 193.7 | 38.5 | 31.7 | 116.4 | 96.6 | 133.2 | 117.3 | 73.7 | 47.4 | 124.7 |
| Hypotaurine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 204.5 | 18.6 | 10.1 | 131.3 |
| Hypoxanthine | 21.3 | 7.5 | 40.8 | 10.8 | 3.6 | 28.5 | 18.6 | 33.5 | 27.7 | 29.0 | 14.2 | 19.4 |
| Inosine | 22.6 | 6.4 | 40 | 4.1 | 2.7 | 18.3 | 17.4 | 9.0 | 23.7 | 22.9 | 13.4 | 13.5 |
| Isobutyric acid | 0 | 4.6 | 0 | 5.4 | 5.8 | 0 | 0 | 3.3 | 4.3 | 6.2 | 6.2 | 3.6 |
| Isoleucine | 143.9 | 35.6 | 193.7 | 39.4 | 43.7 | 132.3 | 111.0 | 122.1 | 108.7 | 79.6 | 90.0 | 104.6 |
| Ketoleucine | 0 | 7.1 | 0 | 5.0 | 6.2 | 0 | 0 | 5.6 | 3.4 | 3.2 | 4.7 | 2.8 |
| Kynurenine | 11.4 | 1.6 | 5.6 | 2.1 | 3.1 | 6.7 | 14.5 | 16.7 | 18.7 | 5.4 | 3.0 | 13.8 |
| Leucine | 255.5 | 71.2 | 374.4 | 74.6 | 72.0 | 264.6 | 216.3 | 240.6 | 188.8 | 179.8 | 156.4 | 257.5 |
| L-Lactic acid | 4033.9 | 2278.2 | 7359.4 | 2735.3 | 2881.5 | 4366.5 | 4470.4 | 3960.2 | 4062.8 | 4510.0 | 3127.2 | 3781.6 |
| Lysine | 37.6 | 19.9 | 49.0 | 19.3 | 18.1 | 38.9 | 46.4 | 11.9 | 20.8 | 39.4 | 26.7 | 33.8 |
| Met-3-OHKG | 2.7 | 0 | 2.4 | 0 | 0 | 1.2 | 1.6 | 8.2 | 8.4 | 7.3 | 2.8 | 1.1 |
| Methionine | 60.8 | 18.0 | 59.4 | 27.4 | 20.3 | 52.1 | 72.6 | 68.0 | 39.0 | 35.4 | 40.9 | 33.7 |
| myo-Inositol | 5472.6 | 601.6 | 13737.5 | 965.7 | 504.3 | 9129.9 | 3749.4 | 8216.5 | 15078.0 | 2299.2 | 1042.4 | 17379.4 |
| NAD | 8.5 | 0.3 | 9.7 | 3.6 | 0.1 | 20.2 | 16.1 | 8.2 | 24.0 | 5.6 | 2.0 | 48.1 |
| Nicotinamide | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ornithine | 47.1 | 7.1 | 0 | 0 | 0 | 0 | 0 | 0 | 85.8 | 44.2 | 0 | 84.5 |
| Phenylalanine | 282.4 | 96.1 | 400.3 | 107.8 | 105.7 | 317.6 | 259.6 | 333.1 | 326.2 | 176.9 | 123.2 | 245.4 |
| Phosphocholine | 65.9 | 5.7 | 232.4 | 10.4 | 6.7 | 108.5 | 41.8 | 96.2 | 183.1 | 41.3 | 10.0 | 301.7 |
| Proline | 53.5 | 17.2 | 210.9 | 23.0 | 33.9 | 91.9 | 116.3 | 62.5 | 42.4 | 39.4 | 23.5 | 35.3 |
| Propylene glycol | 0 | 25.6 | 34.9 | 12.9 | 9.6 | 0 | 37.5 | 11.5 | 13.5 | 8.8 | 8.1 | 12.1 |
| Pyroglutamic acid | 389.2 | 88.4 | 1148.9 | 131.6 | 153.6 | 780.3 | 473.7 | 863.9 | 718.8 | 244.2 | 130.3 | 672.5 |
| Pyruvic acid | 39.0 | 18.2 | 54.2 | 18.7 | 11.5 | 30.4 | 51.9 | 27.4 | 0 | 0 | 20.9 | 25.8 |
| scyllo-Inositol | 80.7 | 16.0 | 142.0 | 16.6 | 9.6 | 145.6 | 64.9 | 107.3 | 263.2 | 44.2 | 21.3 | 217.2 |
| Serine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 327.2 | 180.1 | 132.6 | 208.8 |
| Succinic acid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taurine | 179.2 | 51.9 | 412.8 | 42.8 | 38.4 | 240.5 | 156.3 | 324.4 | 204.1 | 76.1 | 34.6 | 294.9 |
| Threonine | 255.5 | 0 | 0 | 0 | 0 | 277.9 | 302.8 | 225.8 | 400.6 | 176.9 | 47.4 | 482.8 |
| Tryptophan | 121.0 | 34.2 | 142.0 | 45.6 | 28.3 | 105.9 | 50.5 | 103.6 | 145.9 | 76.6 | 38.9 | 84.5 |
| Tyrosine | 295.8 | 85.4 | 516.5 | 95.3 | 96.1 | 277.9 | 274.0 | 359.0 | 417.7 | 182.8 | 104.2 | 261.5 |
| UDP | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 23.7 | 108.7 | 0 | 0 | 152.9 |
| UMP | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 4.7 | 3.1 | 1.9 | 10.1 |
| Uric acid | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 7.2 | 39.6 | 15.2 | 10.4 |
| Uridine | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 13.2 | 11.2 | 7.4 | 16.6 |
| Valine | 564.7 | 174.4 | 658.5 | 169.9 | 177.7 | 529.3 | 389.4 | 555.2 | 429.2 | 324.3 | 246.4 | 462.7 |
| Properties / Samples | CatLens1-5c | CatLens2-6c | CatLens3-8c | CatLens4-9c | CatLens5-10c | CatLens6-11c | CatLens7-12c | CatLens8-13c | CatLens9-l4 | CatLens10-l18 | CatLens11-l24 | CatLens12-l25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… | Human lens catara… |
| Description | CM14-10-5, Glauco… | CM14-10-6, cortex… | CM14-10-8, cortex… | CM14-10-9, cortex… | CM14-10-10, COPD,… | CM14-10-11, corte… | CM14-10-12, corte… | CM14-10-13, HTN, … | CF14-10-4, 4 lens… | CF14-10-18, 18 le… | CF14-10-24, 24 le… | CF14-10-25, 25 le… |
| Species | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… | Human (Homo sapie… |
| Tissue | Lens | Lens | Lens | Lens | Lens | Lens | Lens | Lens | Lens | Lens | Lens | Lens |
| Diseases |
Cataract
Glaucoma |
Cataract | Cataract | Cataract |
Cataract
COPD |
Cataract | Cataract |
Cataract
HTN |
Cataract | Cataract | Cataract | Cataract |
| Gender | male | male | male | male | female | female | female | female | female | female | female | female |
| Origin | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Sample weight, mg | 111.0 | 123.8 | 115.6 | 110.2 | 95.1 | 112.8 | 103.5 | 123.4 | 156.5 | 151.9 | 94.5 | 111.3 |
| Sampling place | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) | Novosibirsk State Regional Clinical Hospital (Fursova) |
| Sampling date | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 | Oct. 28, 2014 |
| Age, months | 852 | 804 | 852 | 876 | 840 | 780 | 768 | 828 | 948 | 936 | 924 | 972 |