Human cornea and aqueous humour (keratoconus)

Description:
Comparison of metabolomic compositions of human cornea and aqueous humor (AH) taken from keratoconus patients and normal post-mortem donors *Reference*: O.A. Snytnikova, L.V. Yanshole, I.A. Iskakov, V.V. Yanshole, V.V. Chernykh, D.A. Stepakov, V.P. Novoselov, Yu.P. Tsentalovich, Quantitative metabolomic analysis of the human cornea and aqueous humor, Metabolomics (2017) 13:152. DOI 10.1007/s11306-017-1281-0
Property Value
Experiment name Human cornea and aqueous humour (keratoconus)
Experiment ID 205
Sample groups Human AH kerat, Human AH norm, Human Cornea kerat, Human Cornea norm
Species Human (Homo sapiens)
Tissues Aqueous humor, Cornea
Diseases Keratoconus
Date of creation 11:29, Sep 13, 2021
Date of last modification 18:22, Jun 09, 2023
Author y.tsentalovich
Charts:
Concentration table
Average concentrations of metabolites in groups. Average ± Std.Dev., in nmol per gram of wet tissue (nmol/g).
Metabolites / Groups Human AH kerat Human AH norm Human Cornea kerat Human Cornea norm
2-Hydroxy-3-methylbutyric acid 6.7 ± 3.4 70.3 ± 61.9 1.4 ± 3.7 46.4 ± 47.2
2-Hydroxybutyric acid 41.8 ± 25.1 160.0 ± 116.8 21.8 ± 16.7 155.5 ± 235.4
3-Hydroxybutyric acid 51.8 ± 34.4 328.0 ± 551.2 23.1 ± 21.8 73.4 ± 110.7
3-Hydroxykynurenine 0.2 ± 0.1 0.2 ± 0.2 0.1 ± 0.1 0.1 ± 0.3
3-Methyl-2-oxovaleric acid 0 ± 0 9.2 ± 8.4 0 ± 0 0.5 ± 1.9
Acetic acid 131.1 ± 31.3 874.7 ± 681.2 3522.0 ± 1879.7 595.1 ± 290.0
Acetylcarnitine 3.1 ± 1.0 22.1 ± 10.5 21.3 ± 6.9 12.7 ± 6.8
Adenosine 0.1 ± 0.1 0.4 ± 0.3 26.0 ± 23.4 10.2 ± 9.9
Adenosylhomocysteine 0.0 ± 0.0 1.1 ± 1.1 4.4 ± 2.3 5.2 ± 3.2
Alanine 212.1 ± 50.3 683.1 ± 315.6 223.8 ± 61.5 322.2 ± 140.5
AMP 0.0 ± 0.0 0.3 ± 0.5 6.9 ± 5.7 3.1 ± 3.0
Arginine 116.7 ± 82.4 109.7 ± 51.5 39.0 ± 35.2 36.9 ± 29.9
Ascorbic acid 324.6 ± 146.8 346.7 ± 208.3 342.2 ± 135.3 130.5 ± 114.1
Asparagine 27.1 ± 13.4 22.1 ± 43.2 29.7 ± 14.5 18.6 ± 19.2
Aspartic acid 2.3 ± 2.5 30.7 ± 21.7 32.2 ± 15.9 23.1 ± 14.0
Benzoic acid 0 ± 0 0 ± 0 133.5 ± 46.5 98.0 ± 35.7
Betaine 10.1 ± 3.6 37.9 ± 25.1 7.2 ± 4.6 13.6 ± 11.8
Carnitine 15.3 ± 4.8 69.1 ± 62.1 25.4 ± 13.9 36.3 ± 10.6
Choline 6.8 ± 1.5 165.9 ± 73.3 30.2 ± 8.8 71.3 ± 27.0
Citric acid 33.3 ± 7.9 54.2 ± 32.3 667.4 ± 349.5 31.2 ± 36.7
CMP 0.0 ± 0.0 0.4 ± 0.8 4.8 ± 2.2 3.2 ± 3.0
Creatine 79.0 ± 11.5 403.7 ± 303.9 67.0 ± 18.4 170.8 ± 143.9
Creatinine 28.1 ± 5.9 80.9 ± 72.0 10.5 ± 5.6 41.0 ± 39.4
Cystathionine 0.0 ± 0.0 0.6 ± 0.8 0.3 ± 0.2 0.5 ± 0.7
Cysteine 6.5 ± 3.5 29.0 ± 11.6 2.9 ± 3.7 9.1 ± 8.0
Cytidine 0.9 ± 0.5 1.9 ± 1.5 4.7 ± 2.9 8.4 ± 6.9
Deoxyguanosine 0.2 ± 0.5 0 ± 0 0.2 ± 0.5 0.3 ± 1.1
Formic acid 22.0 ± 1.9 28.7 ± 13.3 301.4 ± 100.5 229.2 ± 63.5
Fumaric acid 0 ± 0 9.8 ± 6.8 7.8 ± 2.9 11.3 ± 5.7
Glucose 3007.9 ± 666.8 146.8 ± 258.9 344.7 ± 188.3 156.2 ± 461.0
Glutamic acid 10.7 ± 16.4 425.1 ± 238.8 278.8 ± 142.7 276.5 ± 118.7
Glutamine 322.0 ± 170.5 285.1 ± 393.2 170.7 ± 108.3 302.5 ± 166.9
Glycerol 47.4 ± 26.8 1199.9 ± 481.9 115.6 ± 71.1 492.0 ± 179.7
Glycine 17.7 ± 7.4 258.9 ± 160.3 126.5 ± 22.0 239.4 ± 103.9
GMP 0.0 ± 0.0 0.1 ± 0.2 2.7 ± 1.7 1.0 ± 1.3
GSH 0.3 ± 0.6 1.2 ± 2.5 3.3 ± 3.0 5.4 ± 8.3
GSSG 0.1 ± 0.1 0.5 ± 0.8 22.7 ± 14.9 11.0 ± 9.8
Guanine 0.0 ± 0.0 0.4 ± 0.5 0.6 ± 0.4 0.3 ± 0.4
Guanosine 0 ± 0 0.8 ± 0.6 4.0 ± 3.1 4.0 ± 3.2
Histidine 48.2 ± 11.9 64.6 ± 32.2 30.2 ± 12.0 34.5 ± 14.6
Hypotaurine 0.5 ± 0.4 8.9 ± 9.8 9.8 ± 4.2 9.6 ± 8.6
Hypoxanthine 1.0 ± 0.7 150.8 ± 70.7 16.9 ± 10.4 48.6 ± 19.6
Inosine 1.9 ± 1.1 36.2 ± 19.1 43.7 ± 23.4 42.2 ± 23.1
Isobutyric acid 15.5 ± 2.0 21.1 ± 14.4 7.7 ± 2.2 8.3 ± 5.7
Isoleucine 55.4 ± 12.5 105.8 ± 40.9 34.2 ± 11.4 53.8 ± 24.3
Ketoleucine 12.6 ± 11.6 2.5 ± 4.8 5.4 ± 3.7 3.9 ± 5.3
Kynurenine 0.8 ± 0.4 1.7 ± 1.1 0.8 ± 0.4 1.5 ± 0.8
Leucine 156.2 ± 27.3 260.2 ± 107.3 87.7 ± 35.4 125.2 ± 67.9
L-Lactic acid 3884.0 ± 1079.2 25238.3 ± 7697.9 3788.7 ± 1318.3 10151.3 ± 4230.1
Lysine 97.1 ± 49.4 135.2 ± 69.8 26.8 ± 17.7 34.3 ± 27.1
Methionine 24.4 ± 12.1 25.2 ± 13.1 18.8 ± 8.1 14.2 ± 11.3
myo-Inositol 93.9 ± 24.5 566.9 ± 285.3 83.1 ± 22.8 264.4 ± 107.3
NAD 0 ± 0 0 ± 0 19.7 ± 9.7 5.2 ± 5.5
Nicotinamide 0 ± 0 19.1 ± 9.4 0 ± 0 0 ± 0
Ornithine 0 ± 0 28.5 ± 40.9 0 ± 0 0 ± 0
Phenylalanine 90.2 ± 17.5 141.5 ± 65.8 99.1 ± 42.8 67.4 ± 36.0
Phosphocholine 8.2 ± 2.2 62.6 ± 69.7 61.5 ± 24.5 33.1 ± 14.7
Proline 9.3 ± 4.8 59.7 ± 72.8 35.6 ± 17.0 47.5 ± 50.9
Propylene glycol 32.2 ± 9.5 145.6 ± 130.4 44.6 ± 16.3 44.8 ± 24.2
Pyroglutamic acid 23.7 ± 11.7 94.7 ± 46.0 14.1 ± 6.1 20.8 ± 19.1
Pyruvic acid 114.1 ± 33.8 21.2 ± 14.5 25.9 ± 9.0 24.4 ± 13.3
Serine 86.5 ± 47.5 74.9 ± 77.1 120.9 ± 53.9 86.0 ± 86.6
Succinic acid 0 ± 0 233.4 ± 103.5 17.5 ± 6.4 79.5 ± 46.5
Taurine 33.3 ± 16.8 436.7 ± 436.7 636.2 ± 329.0 719.8 ± 231.5
Threonine 123.3 ± 45.5 137.4 ± 154.9 1.1 ± 3.5 47.2 ± 51.8
Tryptophan 25.8 ± 3.5 33.6 ± 13.4 30.9 ± 17.9 33.5 ± 29.6
Tyrosine 77.0 ± 20.8 101.9 ± 59.7 56.1 ± 15.1 61.4 ± 32.1
UMP 0 ± 0 0.1 ± 0.3 5.3 ± 3.7 2.3 ± 3.3
Uric acid 36.9 ± 21.8 133.0 ± 104.2 102.5 ± 48.9 112.7 ± 96.1
Uridine 3.2 ± 4.1 37.4 ± 15.9 9.6 ± 14.3 27.0 ± 11.7
Valine 283.8 ± 56.1 257.5 ± 96.6 152.0 ± 40.4 141.4 ± 64.1
Full concentration table
Concentration of metabolites in samples, in nmol per gram of wet tissue (nmol/g).
Metabolites / Samples KeratAH1 KeratAH2 KeratAH3 KeratAH4 KeratAH5 KeratAH6 KeratAH7 NormAH1 NormAH2 NormAH3 NormAH4 NormAH5 NormAH6 NormAH7 NormAH8 NormAH9 NormAH10 NormAH11 NormAH12 NormAH13 KeratCorn1 KeratCorn2 KeratCorn3 KeratCorn4 KeratCorn5 KeratCorn6 KeratCorn7 KeratCorn8 KeratCorn9 KeratCorn10 KeratCorn11 NormCorn1 NormCorn2 NormCorn3 NormCorn4 NormCorn5 NormCorn6 NormCorn7 NormCorn8 NormCorn9 NormCorn10 NormCorn11 NormCorn14 NormCorn15
2-Hydroxy-3-methylbutyric acid 6.4 6.8 10.6 10.6 2.6 8.0 2.1 57.6 18.3 59.5 203.1 41.2 16.8 109.1 18.5 15.4 143.1 147.0 13.1 70.5 0 0 0 0 0 0 0 0 0 3.6 12.1 157.3 94.5 28.1 72.5 19.4 10.0 37.4 5.4 0 30.3 26.0 16.2 106.3
2-Hydroxybutyric acid 25.6 78.8 32.9 77.7 28.3 27.9 21.5 119.7 166.5 48.3 131.6 141.5 119.1 442.2 113.9 90.8 367.0 93.6 51.9 193.9 12.8 51.2 15.3 37.6 13.4 0 0 11.8 31.1 26.6 39.6 326.7 859.4 18.1 68.0 47.1 59.9 152.8 51.3 58 24.8 22.8 29.5 303.6
3-Hydroxybutyric acid 21.3 112.5 20.8 85.4 38.6 46.5 37.6 133 249.7 44.6 140.8 164.7 63.7 176.3 82.5 42.4 1981.9 190.5 42.3 951.9 21.3 80.6 0 42.8 13.4 10.9 14.6 20.0 23.3 17.3 10.3 60.5 94.5 10.0 52.3 71.1 25.0 53.5 23.3 22.0 36.7 36.1 35.3 433.7
3-Hydroxykynurenine 0.4 0.2 0.2 0.1 0.2 0.2 0 0 0.2 0.1 0.1 0.1 0.2 0.3 0.2 0.8 0 0 0.2 0.1 0 0.1 0.1 0.2 0.1 0.4 0 0 0 0 0 0.2 0 0.2 0 0 0 1.0 0 0 0 0 0 0.2
3-Methyl-2-oxovaleric acid 0 0 0 0 0 0 0 8.9 6.7 3.2 12.7 7.7 6.6 0 11.8 2.1 29.4 9.0 0 21.2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0
Acetic acid 145.0 128.3 157.3 170.8 126.1 115.2 75.2 1463.0 114.9 1244.8 1569.5 193 1047.5 503.7 1335.4 99.8 2202.1 434.4 105.7 1057.7 4122.3 422.2 1986.7 4905.5 6037.2 4899.5 2587.6 3173.1 6218.9 1461.5 2927.7 907.6 309.4 580.1 1233.4 341.6 873.9 328.6 691.9 417.6 789.1 278.7 562.1 422.8
Acetylcarnitine 3.8 2.9 4.0 4.4 1.6 3.0 2.1 27.9 16.7 10.2 30 46.3 10.5 25.2 12.0 30.3 26.8 23.7 15.4 12.7 29.9 20.5 18.3 24.0 31.9 20.4 30.4 11.8 14.3 15.9 17.2 11.4 7.9 6.3 11.2 27.7 15.8 9.9 7.8 23.2 11.9 7.0 5.9 18.4
Adenosine 0.2 0.1 0.1 0.1 0.1 0.1 0 0.3 0.5 0.1 0.1 0.5 0.4 0.4 0.2 0.4 0.4 1.4 0.2 0.1 23.3 33.1 13.8 17.8 86.5 46.5 0 13.7 11.7 21.0 18.1 1.3 10.7 15.7 7.7 4.2 17.3 12.4 14.3 36.3 0 0 11.0 1.9
Adenosylhomocysteine 0.1 0.0 0.0 0.0 0.0 0.0 0 0.6 0.8 0.2 0.5 1.5 0.7 4.7 0.7 1.4 0.8 1.2 1.5 0.3 8.4 5.9 6.3 3.0 3.9 5.9 0 2.3 5.2 3.6 4.1 5.8 4.3 5.9 6.1 3.7 10.8 6.7 8 9.2 0 0 3.3 3.9
Alanine 191.9 191.3 311.2 201.9 218.7 223.0 147.0 780.3 532.7 334.4 380.8 900.7 451.9 1230 569.5 242.0 880.8 969.0 1114.6 493.6 298.5 230.3 351.5 198.3 167.7 176.9 135 199.8 233.2 212.6 258.3 363.1 257.8 163.2 314.0 461.6 341.2 534.9 248.8 150.8 312.0 253.3 181.0 607.1
AMP 0 0 0 0 0 0.0 0 1.3 0.3 0.0 0.0 0.1 0.1 0.3 0 0.1 0 0.1 1.7 0 4.4 1.7 4.7 15.1 9.7 0 0 3.7 14.0 8.5 14.4 0.6 3.7 2.2 1.3 0.9 7.9 0.3 4.0 4.9 0 0 7.3 7.7
Arginine 79.2 69.4 88.9 251.8 169.1 158.2 0 117.9 66.8 86 60.8 65.7 124.8 257.5 98.6 118.0 88.4 130.0 136.7 74.9 49.2 40.1 38.4 44.5 99.1 105.0 0 16.4 16.9 13.2 6.5 60.1 18.0 30.8 106.5 37.9 69.1 52.0 22.2 10.6 0 0 32.2 40.0
Ascorbic acid 409.4 337.5 484.1 452.9 295.9 234.1 58.1 359.1 148.1 78.0 237.7 213.6 739.4 279.9 687.4 184.6 587.2 250.6 442 299.7 554.4 524.5 504.3 313.1 310.3 272.2 135 211.5 388.7 292.3 258.3 145.2 30.1 63.5 127.1 59.1 407.8 61.1 225.4 90.5 201.9 22.2 247.7 15.2
Asparagine 35.8 19.8 36.2 33 36.8 28.3 0 0 0 0 0 87.5 0 123.1 0 0 0 0 76.9 0 49.6 35.5 50.8 21.0 23.9 25.9 0 22 41.6 26.0 30.9 42.5 28.6 32.9 8.5 20.8 12.6 7.6 6.1 0 0 0 18 64.5
Aspartic acid 1.5 0.3 1.2 3.4 7.4 1.9 0 79.8 15.0 5.0 16.2 51.5 12.1 28.0 13.8 30.3 31.9 46.8 53.8 15.5 47.5 24.9 27.1 24.9 65.0 29.5 0 33.7 32.0 31.8 37.7 36.3 6.0 0 36.6 25.9 37.5 19.1 36.5 0 35.8 22.2 17.2 27.1
Benzoic acid 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 142.2 127.9 152.8 114.8 83.9 122.5 90 75.2 202.1 132.9 223.9 145.2 94.5 99.7 97.2 92.3 91.6 64.2 73.9 95.1 55.1 50.7 152.4 162.6
Betaine 9.4 8.3 10.7 17.3 7.2 10.6 6.8 32.8 20.0 13.6 12.7 92.6 20.5 67.2 16.7 42.4 62.4 22.1 59.6 30.0 10.2 11.3 9.0 16.7 2.9 4.2 1.9 4.4 3.1 5.1 10.3 15.7 10.3 0 10.5 47 15.0 0 6.2 17.4 18.4 6.3 16.2 14.1
Carnitine 14.5 11.7 19.0 24.3 11.3 11.3 14.7 177.3 23.3 18.6 18.2 100.4 39.0 50.4 28.7 57.5 77.1 217.2 53.8 37.0 29.9 23.0 56.5 23.0 13.4 23.1 11.3 12.9 21.8 19.9 44.8 38.7 23.2 27.2 28.4 61.9 45.8 31.3 39.7 36.0 45.9 30.4 25.7 38.0
Choline 6.8 6.8 7.8 9.3 4.9 7.3 5.1 248.3 78.2 109.6 143.1 205.9 106.8 170.7 176.8 72.6 330.3 227.2 126.8 160.4 46.9 33.3 42.8 28.2 31.9 20.4 30.4 23.5 32.7 18.6 24.1 88.3 43.8 33.5 85.2 111.7 108.2 45.9 68.4 51.0 110.1 58.9 53.4 68.3
Citric acid 38.4 20.3 43.2 38.8 28.3 35.3 29.1 141.9 41.6 27.9 36.9 56.6 45.2 42.0 27.5 45.4 99.1 63.5 32.7 44.1 852.9 121.5 519.6 835.0 1090.1 952.7 562.5 528.9 1057.2 46.5 775.0 0 0 0 59.8 46.2 124.8 21.4 19.4 23.2 0 0 57.2 54.2
CMP 0 0 0.0 0 0 0 0 2.7 0.3 0.0 0.1 0.4 0 1.2 0.1 0 0 0.7 0.2 0.1 8.1 5.0 5.9 4.7 2.8 3.5 0 3.8 6.0 6.4 6.6 5.0 1.7 5.6 1.6 1.0 8.8 0.7 1.9 5.7 0 0 7.8 2.4
Creatine 89.6 56.3 81.3 90.6 77.2 76.2 82.0 576.3 128.2 92.9 175.4 1055.1 191.0 363.8 237.6 175.5 587.2 902.2 480.4 282.1 105.2 71.6 79.5 47.0 58.7 38.1 61.9 52.9 70.0 71.8 80.9 338.9 103.1 58.0 127.1 572.4 133.2 175.7 116.6 109.0 119.3 240.7 86.7 40.1
Creatinine 34.5 27 31.1 33.7 25.7 27.9 17.1 53.2 51.6 63.2 46.2 283.1 45.2 28 66.8 181.5 91.8 60.2 36.5 44.1 14.2 16.6 22.9 9.1 7.0 4.1 4.8 7.5 8.2 9.3 12.1 25.4 20.6 16.3 17.2 120.0 19.1 32.9 21.0 65.0 22.0 19 23.8 130.1
Cystathionine 0 0.0 0.1 0.0 0 0.0 0 0.5 0.5 0.2 0.1 1.1 0.1 1.7 0.2 3.0 0.4 0.2 0.4 0.2 0.5 0.4 0.2 0.3 0.1 0.3 0 0.3 0.3 0.3 0.6 0.3 0 0.4 0 0.7 0.3 1.0 0 2.2 0 0 0 1.9
Cysteine 7.1 4.8 6.3 10.4 10.2 7.0 0 6.2 20.6 15.5 21.7 36.4 27.7 46.3 36.2 41.3 28.6 43.5 23.7 28.9 0.8 0.8 0.4 5.3 9.7 10.0 0 0.8 1.0 1.4 1.8 9.8 4.4 2.2 8.0 23.4 4.1 21.9 8.6 16.3 0 0 3.0 16.2
Cytidine 1.7 0.9 1.2 1.0 0.8 0.7 0 1.1 0.7 1.3 2.5 2 2.0 1.2 5.5 0.8 1.4 2.2 0 4.4 6.4 10.2 6.3 8.1 1.5 2.6 0 3.5 4.5 3.8 4.6 14.1 0 13.5 17.5 6.9 8.9 6.5 15.2 19.6 0 0 4.2 3.3
Deoxyguanosine 1.4 0.1 0.2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.7 0.3 0.4 0 0 0 0 0 0 0 0 0 0 4.0 0 0 0 0 0 0 0 0 0 0
Formic acid 24.7 20.0 22.5 22.5 19.8 20.4 23.9 38.6 16.7 16.4 18.2 36.0 16.2 13.7 27.5 24.8 33.0 60.2 40.4 31.7 255.9 191.9 275.1 375.7 293.5 490.0 213.8 164.5 435.3 292.3 327.2 266.2 189.1 136.0 276.6 332.4 199.7 145.2 202.1 243.6 229.4 202.7 209.6 346.9
Fumaric acid 0 0 0 0 0 0 0 12.9 12.8 3.2 5.8 12.9 5.8 9.2 7.9 4.5 8.4 29.4 10.2 4.1 13.2 12.3 9.2 7.4 4.5 9.3 7.2 4.1 5.8 6.6 6.0 12.1 8.6 10.9 20.9 15.7 19.1 7.6 11.7 9.6 17.4 7.0 2.3 3.7
Glucose 3283.6 2520.1 3803.4 3960.0 2547.6 2582.5 2358.4 97.5 78.2 107.8 101.6 30.9 18.5 475.8 23.6 27.2 44 0 903.2 0 341.2 383.8 152.8 574.1 243.2 176.9 168.8 235.1 311.0 757.3 447.8 39.9 0 0 0 0 0 122.3 0 0 0 25.3 162.0 1680.5
Glutamic acid 6.1 3.1 4.8 14.9 46.0 0 0 975.3 366.2 180.2 180.0 411.7 246.5 503.7 333.9 160.4 770.7 568.1 442 387.8 611.2 447.8 366.8 219.2 176.1 285.8 247.5 152.8 171.0 199.3 189.4 508.3 154.7 172.2 470.9 304.7 283.0 198.7 272.1 301.6 376.2 139.3 152.4 260.2
Glutamine 416.6 295.2 419.9 448.2 469.5 204.5 0 1019.7 499.4 594.5 0 823.5 0 0 0 0 0 0 768.7 0 213.2 84.4 320.9 157 126 0 0 223.3 280 265.7 206.7 411.5 189.1 126.9 149.5 424.7 274.7 557.8 202.1 174 211.0 253.3 285.8 672.2
Glycerol 34.1 54 79.5 0 38.6 74.3 51.3 1551.7 582.6 910.4 946.3 1286.7 924.3 1539.2 1414.0 251.1 1798.4 935.6 1748.8 1710.0 184.8 102.4 214.0 0 134.2 108.9 56.3 29.4 155.5 79.7 206.7 726.1 266.4 281.0 560.6 553.9 607.6 641.8 559.7 232 743.2 272.3 409.7 542.1
Glycine 14.1 15.8 32.9 17.1 10.6 20.4 13.0 301.5 134.8 176.5 163.9 283.1 293.7 587.7 432.1 223.9 0 467.8 144.1 156.9 156.4 107.5 152.8 104.4 100.6 163.3 112.5 129.3 125.9 124.9 113.7 278.3 146.1 108.8 328.9 258.5 382.8 420.3 194.3 116 312.0 152 142.9 271.0
GMP 0 0 0 0.0 0 0 0 0.6 0.1 0 0.0 0.1 0 0.1 0 0 0 0.4 0.3 0.0 2.6 1.5 2.9 3.6 3.0 0 0 2.4 5.7 3.4 4.7 0.3 1.1 1.2 0.4 0.3 2.3 0 0.8 0 0 0 4.4 1.9
GSH 0 0 0 0.3 0.1 1.5 0 0.8 0.1 0 1.5 1.0 0 9.2 2.8 0.1 0 0 0.2 0 4.8 1.5 1.4 9.0 7.8 2.0 0 2.8 4.5 0 2.1 0 0.4 1.5 18.1 4.5 27.7 3.7 2.2 8.4 0 0 1.3 2.6
GSSG 0 0 0 0.1 0.1 0.1 0 0 1.3 0 0.3 1.0 0 2.6 0.2 0.4 0 0 0.5 0 51.5 26.7 41.2 24.9 23.0 2.1 0 14.8 23.5 16.6 25.1 15.0 9.9 19.3 8.8 2.2 35.4 2.2 13.6 18.9 0 0 9.0 8.6
Guanine 0 0 0 0.1 0.0 0.1 0 1.5 0.8 0.9 0.3 0.1 0.4 0.1 0.0 0.2 0.0 0.1 1.0 0 0 0.7 0.8 0.7 1.1 1.4 0 0.6 0.7 0.4 0 0.6 0 0.4 0.7 0.9 0 0 0 0.2 0 0 0 0.9
Guanosine 0 0 0 0 0 0 0 2.4 1.4 0.4 0.3 0.5 0 0.7 0.2 1.2 0.2 0.7 0.9 0.9 3.4 7.2 2.3 2.4 4.5 11.9 0 2.5 2.9 3.4 3.6 3.5 3.8 4.5 3.3 2.7 3.2 6.6 3.8 12.7 0 0 4.9 3.7
Histidine 51.2 42.8 70.9 44 48.9 48.3 31.5 93.1 38.3 59.5 43.9 84.9 57.5 50.4 58.9 63.5 110.1 123.6 0 56.4 64.0 32.0 27.5 25.1 27.7 27 23.6 27.0 26.4 17.3 34.4 38.7 21.5 26.3 35.9 25.9 45.8 67.2 24.9 34.8 17.4 27.2 25.7 57.5
Hypotaurine 0 0.5 0.8 0.7 0.9 0.7 0 21.4 7.8 3.4 5.7 36.8 3.4 10.4 3.7 3.8 2.2 3.7 4.4 8.6 14.8 8.7 12.2 11.3 13.5 5.4 0 12.1 8.6 8.8 12.1 13.1 12.8 16.6 6.1 24.5 5.3 5.8 2.4 0 0 0 23.5 15.1
Hypoxanthine 1.8 0.4 1.1 1.8 0.8 1.1 0 115.3 88.2 87.3 73.9 208.4 131.5 212.7 147.3 54.5 275.3 220.5 230.6 114.6 39.3 23.4 26.5 14.5 12.2 14.1 0 11.0 22.3 10.9 11.4 60.5 30.9 32.6 47.8 52.6 49.9 66.5 42.8 23.2 55.1 45.0 27.6 97.6
Inosine 3.7 2.0 2.1 2.5 1.7 1.6 0 57.0 31.4 19.0 27.2 42.1 33.6 82.7 28.5 48.4 23.0 16.5 46.4 14.6 70.5 55.3 49.4 39.5 90.6 32.4 0 33.6 36.7 42.3 30.2 52.9 43.5 34.2 30 26.0 66.9 61.3 56.8 68.4 0 0 48.3 60.2
Isobutyric acid 14.9 17.3 13.5 18.1 12.9 14.9 17.1 13.3 20.0 11.7 10.4 28.3 18.7 61.6 15.7 21.8 36.7 11.0 9.0 16.8 8.5 8.4 6.9 10.4 7.0 6.8 5.6 5.9 10.9 4.4 10.3 15.7 12.9 0 2.2 12 8.3 17.6 7 5.8 4.6 1.6 6.4 14.1
Isoleucine 64.0 49.5 77.8 56.9 41.2 53.9 44.4 164.0 63.3 66.9 115.4 87.5 106.8 117.5 117.8 30.3 187.2 110.3 117.2 91.7 58.3 42.2 47.4 29.2 20.1 38.1 31.5 24.7 23.3 31.9 29.3 85.9 31.8 36.3 82.2 46.2 67.4 47.4 41.2 19.7 69.7 29.8 44.8 97.6
Ketoleucine 37.1 5.4 7.8 17.1 7.7 8.7 4.4 4.4 5.5 0 16.4 0 0 0 0 0 0 0 0 5.8 8.8 10.6 11.2 6.3 3.8 0 0 5.3 3.1 4.4 6.0 0 0 0 9.7 0 5.6 2.3 2.3 3.5 0 0 16.2 10.8
Kynurenine 1.1 0.6 0.9 0.7 1.1 1.1 0 2.1 1.4 0.7 0.9 2.2 1.2 3.7 1.2 4.2 1.1 0.8 1.9 0.8 1.1 0.6 1.0 0.8 0.6 1.3 0 0.5 0.7 0.8 1.1 1.2 1.6 1.3 0.9 2.1 1.2 2.4 1.6 2.9 0 0 1.8 2.0
Leucine 170.6 157.5 190.2 152.7 102.9 148.6 170.9 341.4 154.8 159.8 277.0 205.9 195.1 419.8 216.0 87.7 440.4 367.6 288.3 229.2 127.9 140.7 129.9 69.9 58.7 125.2 66.4 52.9 49.8 62.5 80.9 145.2 68.8 75.2 224.3 110.8 124.8 160.5 85.5 63.8 119.3 69.7 87.7 292.7
L-Lactic acid 3539.5 5512.6 4840.7 4451.7 3319.6 3028.4 2495.2 28373.0 23303.6 17650.3 20772.4 26505.4 23004.2 36660.5 19638.7 16034.7 36701.7 23390.5 38434.4 17628.4 5970.2 4989.3 6112.8 3653.1 2767.1 2585.9 2475.1 2938.1 3731.3 2923.1 3530.4 11738.6 9024.0 5438.4 9418.7 11078.6 12484.1 14747.1 6996.3 7424.0 10551.8 4939.9 7526.2 20599.2
Lysine 88.7 79.9 105.8 134.6 150.1 120.5 0 240.8 103.5 109.3 136.6 161.7 79.1 311.3 94 81.8 76.3 98.5 158.3 106.9 49.0 26.3 37.7 34.2 48.2 47.1 0 9.0 15.4 6.9 21.3 47.1 20.8 42.3 61.4 66.6 25.9 50.3 7.1 4.8 0 0 36.7 82.5
Methionine 29.7 16.3 30.7 32.4 31.5 30.1 0 49.3 29.2 26.5 24.5 39.3 7.6 36.3 11.5 10.5 15.0 13.8 39.2 24.8 28.7 19 27.4 14.3 19.6 28.3 0 15.6 18.9 16.7 18.3 23.4 12.5 16.3 36.5 24.5 6.5 8.1 8.8 7.8 0 0 10.5 30.1
myo-Inositol 93.8 92.3 114.1 129.4 92.6 83.6 51.3 1285.7 299.6 334.4 332.4 710.2 369.7 783.6 294.6 695.9 807.4 534.6 480.4 440.7 120.8 102.4 107.0 93.9 58.7 54.4 48.4 88.1 74.6 79.7 86.1 496.2 326.6 108.8 246.7 387.8 249.7 305.6 178.8 301.6 146.8 139.3 257.2 292.7
NAD 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 38.4 15.4 30.6 25.1 16.8 13.6 6.8 7.1 24.9 15.9 22.4 0 0 8.2 0 0 15.8 7.6 7.8 11.6 0 0 9.5 6.5
Nicotinamide 0 0 0 0 0 0 0 20.0 13.3 0 12.5 28.3 15.6 25.5 19.3 7.9 34.9 23.4 28.8 19.4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Ornithine 0 0 0 0 0 0 0 11.5 33.3 0 3.7 51.5 5.3 139.9 0 0 27.5 6.0 78.8 13.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Phenylalanine 102.4 72 119.3 98.4 87.5 79.9 71.8 133 103.2 98.5 87.7 216.2 90.4 307.8 84.5 181.5 179.8 120.3 149.9 86.4 156.4 127.9 152.8 114.8 92.2 149.7 67.5 47.0 48.2 73.1 60.3 52.0 34.4 99.7 82.2 92.3 46.6 107.0 28.8 100.9 45.9 17.7 38.1 130.1
Phosphocholine 9.8 8.8 5.5 8.8 8.0 11.3 5.1 283.7 25.0 6.0 17.8 54.0 61.6 70.0 35.0 37.8 73.4 70.2 42.3 37.0 89.6 70.4 59.6 43.8 47.0 66.7 34.9 27.0 107.3 82.4 48.2 46.0 19.8 24.5 16.5 23.1 40.8 25.2 35.8 62.6 37.6 12.0 51.4 34.7
Proline 15.7 10.2 11.6 10.3 8.8 8.4 0 207.3 61.8 37.0 93.8 176.1 0.2 3.1 0.9 0.8 0.7 1.0 137.3 56.6 65.9 45.9 51.5 26.5 23.3 37.8 0 26.8 38.7 39.5 35.8 123.6 45.9 63.7 109.5 114.0 0.5 2.4 1.1 0.4 0 0 48.6 108.0
Propylene glycol 28.1 42.8 27.7 28.5 20.8 29.7 47.9 190.6 64.9 46.5 196.2 18.0 287.6 475.8 159.1 99.8 205.5 40.1 10.0 98.7 38.4 43.5 26.0 45.9 35.2 44.9 32.6 76.4 62.2 23.9 62 55.7 30.1 21.8 53.1 24.9 76.6 91.7 42.8 26.7 71.6 8.2 36.2 43.4
Pyroglutamic acid 27.4 19.6 26.3 35.2 33.0 24.5 0 133 59.9 74.3 138.5 196 94 67 98 60.5 143.1 26.7 69.2 70.5 17.7 13.9 16.1 12.7 9.7 10.0 0 16.3 21.0 15.8 22.3 54.4 35.2 19.8 23.8 45.9 7.0 9.1 7.0 3.4 0 0 18.1 47.3
Pyruvic acid 68.2 83.3 126.2 160.5 108.1 102.2 150.4 17.7 12.7 18.6 27.7 19.3 15.0 12.0 14.3 39.3 16.5 12.4 61.5 7.9 38.4 19.2 24.5 35.5 16.8 17.7 16.9 29.4 20.2 25.2 41.3 20.6 21.5 19.0 26.2 20.3 41.6 26.0 10.9 18.6 18.4 11.4 21.9 60.7
Serine 94.7 53.7 92.4 103 149.0 112.5 0 262.9 96.7 55.4 76.5 115.5 11.6 25.7 13.5 12.6 12.3 17.2 183.9 90.1 178.8 142.8 173.8 91.9 112.2 197.1 0 99.9 118.4 96.5 118.7 196.5 115.5 100.1 292.4 85.2 23.3 25.6 24.7 27.4 0 0 74.7 153.2
Succinic acid 0 0 0 0 0 0 0 376.8 249.7 139.3 159.3 303.7 236.2 190.3 263.2 90.8 403.7 344.2 83 194 32.7 16.6 22.9 11.5 11.7 13.6 12.5 15.3 21.8 14.6 18.9 145.2 60.2 27.2 41.9 62.8 91.6 84.1 73.1 40.6 100.9 60.2 50.5 195.2
Taurine 46.6 31.8 24.5 40.5 41.1 48.3 0 1649.8 288.1 190.4 323.3 997.5 107.1 479.4 150.7 186.7 102.6 303.6 553.6 344.0 1140 750 780 700 670 480 0 108 870 730 770 1089.2 395.3 634.5 747.5 830.9 915.5 764.1 544.2 475.6 734.0 380 762.2 1084.2
Threonine 115.1 135 152.1 119.1 136.4 174.7 30.8 532.0 40.0 13.3 46 334.5 88 269 80 27.2 84.4 40.1 192 40 0 0 0 0 0 0 0 11.8 0 0 0 44.8 22.4 36.3 135 74 108 137 0 0 0 0 56.2 0
Tryptophan 25.6 29.3 31.1 23.8 24.5 26.0 20.5 22.2 25.0 27.9 16.2 51.5 24.7 56.0 25.5 33.3 58.7 33.4 32.7 30.0 62.5 40.9 33.6 25 33.5 0 0 30.6 40.4 35.9 37.9 60.5 15.5 72.5 0 0 63.3 64.2 0 0 19.3 25.3 47.6 67.2
Tyrosine 76.8 51.8 114.1 82.8 72.1 55.7 85.5 88.7 69.9 72.5 60.0 90.1 71.9 285.5 100.2 69.6 139.5 86.9 121.1 68.8 79.6 49.9 82.5 47.0 36.9 46.3 45 42.3 62.2 59.8 65.4 69.0 40.4 36.3 61.3 64.6 62.4 145.2 49.8 42.9 59.6 24.7 38.1 104.1
UMP 0 0 0 0 0 0 0 1.0 0.1 0 0 0.1 0 0.3 0 0 0 0.1 0.1 0 5.3 2.4 3.9 8.1 7.4 0.1 0 3.9 9.1 6.5 11.8 0.3 1.7 2.8 0.7 0.4 5.6 0.5 0 4.9 0 0 11.6 1.9
Uric acid 33.7 36.1 40.7 72.9 28.5 46.5 0 65.8 88.1 91.2 120.1 311.5 82.8 91.2 97.1 404.6 59.9 62.0 136.2 118.8 197.9 106.7 159.0 105.2 79.0 97.0 0 89.0 93.6 88.4 111.5 101.6 75.1 69.3 130.5 256.4 131.9 66.2 67.8 329.6 0 0 49.9 187.2
Uridine 0 7.2 7.8 7.8 0 0 0 66.5 30.0 26.0 25.4 33.5 20.5 47.6 19.6 33.3 69.7 43.4 38.4 31.7 25.6 39.7 0 0 0 0 0 17.6 0 22.6 0 46.0 31.8 34.4 31.4 19.4 39.1 16.1 14.8 9.3 27.5 18.4 19.1 43.4
Valine 302.8 292.5 380.3 276.9 231.6 297.3 205.1 399 178.1 174.7 219.3 169.8 267.0 419.8 235.7 130.1 403.7 287.4 269.0 193.9 213.2 204.7 198.7 125.3 92.2 149.7 101.3 129.3 139.9 159.4 158.4 205.7 77.4 81.6 164.5 92.3 166.5 236.9 139.9 73.1 156.0 69.7 114.3 260.2
Metadata
Properties / Samples KeratAH1 KeratAH2 KeratAH3 KeratAH4 KeratAH5 KeratAH6 KeratAH7 NormAH1 NormAH2 NormAH3 NormAH4 NormAH5 NormAH6 NormAH7 NormAH8 NormAH9 NormAH10 NormAH11 NormAH12 NormAH13 KeratCorn1 KeratCorn2 KeratCorn3 KeratCorn4 KeratCorn5 KeratCorn6 KeratCorn7 KeratCorn8 KeratCorn9 KeratCorn10 KeratCorn11 NormCorn1 NormCorn2 NormCorn3 NormCorn4 NormCorn5 NormCorn6 NormCorn7 NormCorn8 NormCorn9 NormCorn10 NormCorn11 NormCorn14 NormCorn15
Group Human AH kerat Human AH kerat Human AH kerat Human AH kerat Human AH kerat Human AH kerat Human AH kerat Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human AH norm Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea kerat Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm Human Cornea norm
Description N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Species Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie… Human (Homo sapie…
Tissue Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Aqueous humor Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea Cornea
Diseases Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus Keratoconus N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Gender male male male male female male female male male male male female male male male female male male male male male male male male female male female male female male male male male male male female male male male female male male male female
Origin N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Sample weight, mg 105.0 199.0 259.0 173.0 174.0 241.0 131.0 101.0 269.0 241.0 233.0 254.0 194.0 174.0 218.0 160.0 228.0 148.0 122.0 134.0 38.1 28.8 33.7 26.0 31.5 35.0 29.3 42.9 53.4 32.9 39.8 37.0 52.1 49.4 59.9 48.5 53.8 58.6 57.6 38.6 48.8 70.7 47.0 41.3
Sampling place Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia Novosibirsk, Russia
Sampling date May 30, 2015 May 20, 2015 May 29, 2015 June 18, 2015 June 19, 2015 July 2, 2015 July 9, 2015 April 22, 2015 May 2, 2015 May 27, 2015 June 9, 2015 June 25, 2015 July 8, 2015 July 8, 2015 July 14, 2015 July 21, 2015 July 21, 2015 July 15, 2015 May 22, 2015 May 21, 2015 May 30, 2015 May 20, 2015 May 29, 2015 June 18, 2015 June 19, 2015 July 2, 2015 July 9, 2015 April 7, 2015 April 15, 2015 April 14, 2015 April 16, 2015 April 22, 2015 May 2, 2015 May 27, 2015 June 9, 2015 June 25, 2015 July 8, 2015 July 8, 2015 July 14, 2015 July 21, 2015 July 21, 2015 July 15, 2015 Dec. 3, 2014 Aug. 4, 2014
Age, months 264 612 300 468 348 288 348 408 780 744 372 972 228 552 456 924 480 444 360 348 264 612 300 468 348 288 348 264 396 384 312 408 780 744 372 972 228 552 456 924 480 444 744 876
Time postmortem, min 0 0 0 0 0 0 0 600 600 600 600 600 600 600 600 600 600 600 600 600 0 0 0 0 0 0 0 0 0 0 0 600 600 600 600 600 600 600 600 600 600 600 600 600
Raw files
File types / Samples KeratAH1 KeratAH2 KeratAH3 KeratAH4 KeratAH5 KeratAH6 KeratAH7 NormAH1 NormAH2 NormAH3 NormAH4 NormAH5 NormAH6 NormAH7 NormAH8 NormAH9 NormAH10 NormAH11 NormAH12 NormAH13 KeratCorn1 KeratCorn2 KeratCorn3 KeratCorn4 KeratCorn5 KeratCorn6 KeratCorn7 KeratCorn8 KeratCorn9 KeratCorn10 KeratCorn11 NormCorn1 NormCorn2 NormCorn3 NormCorn4 NormCorn5 NormCorn6 NormCorn7 NormCorn8 NormCorn9 NormCorn10 NormCorn11 NormCorn14 NormCorn15
MS N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
NMR
Total size: 0 B
Download *.csv file